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NCT05680350 Clinical Trial

Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

Endometriosis Clinical Trial

Official title:
Plasma Levels of Micro RNA 203 and 210 Might Spare the Exploratory Laparoscopy in Case of un Explained Infertility With Suspected Endometriosis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05680350
Other study ID # RC 2.6.2022
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 7, 2020
Est. completion date March 25, 2022

Study information
Verified date December 2022
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

Recruitment information / eligibility
Status Completed
Enrollment 100
Est. completion date March 25, 2022
Est. primary completion date November 12, 2021
Accepts healthy volunteers No
Gender Female
Age group 30 Years to 45 Years
Eligibility Inclusion Criteria: - 30-45 years old - Unexplained infertility Exclusion Criteria: - Presence of other causes of infertility, - age out of the predetermined range, - the presence of immune disorders, - maintenance on immunosuppressive drugs

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Laparoscopic Exploration
Laparoscopic Exploration to diagnose & grade endometriosis
Diagnostic Test:
• Estimation of Plasma Expression level of MICRO RNA 203 & 210
estimation of Plasma Expression level for Gene"Micro RNA "203 & 210" by qRT-PCR

Locations
Country Name City State
Egypt Banha University Banha El- Qalyobia

Sponsors (1)
Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary grading of endometriosis The diagnostic performance of estimated plasma levels of microRNA for diagnosis and grading endometriosis 8 months
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