Endometriosis Related Infertility Clinical Trial
Official title:
Surgery Before Embryo Transfer in Endometrioma Related Reduction in Ovarian Reserve
This prospective study evaluates the pregnancy results after laparoscopic endometriosis operation in infertile patients with ERROR (endometrioma related reduction in ovarian reserve)
This study consists of two groups. Patients will be randomly enrolled into the groups by ART
(assisted reproductive technology) centre nursery. All patients will sign a consent form
about procedure.
Patients diagnosed with endometrioma (larger than 3 cm diameter) and ERROR (endometrioma
related reduction in ovarian reserve - Antimullerian Hormon < 1.2 ng/ml, Antral follicle
count < 7 , Day3 Follicle Stimulating Hormone > 10 IU/dl, Low response to ovarian hyper
stimulation < 3 oocytes) will be enrolled in study. Patients with age >40, with male factor,
with undefined adnexal mass, malignity suspicion will be excluded from study.
The study group consists of patients who will undergo laparoscopic endometriosis surgery
after ICSI procedure with freezing all embryos. The patients will wait about 6 months for
spontaneous conception, if there is no pregnancy during this period, frozen embryo transfer
will be performed. The control group consists of patients who will be performed IVF&ICSI
procedure with fresh embryo transfer without surgery. If there is no pregnancy, patients will
be operated then.
As the primary; result positive b-hCG rates will be compared between groups.
In conclusion we will find out whether laparoscopic endometriosis operation improves or
worsens the pregnancy results in patients with ERROR.
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