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Endometrial Neoplasms clinical trials

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NCT ID: NCT06206083 Recruiting - Endometrial Cancer Clinical Trials

Molecular Classification in Mexican Patients With Endometrial Cancer and Its Impact on Prognosis

Start date: March 1, 2024
Phase:
Study type: Observational

Endometrial cancer (EC) is one of the most common gynecological neoplasms, being the second in incidence and third in mortality in Mexico. Recent studies show that EC molecular classification (Cancer Genome Atlas Research Network, 2013) serves to establish a more accurate prognosis in these patients and regulate therapeutic behavior in a personalized manner. However, there are no studies on EC molecular classification in Mexican women or its impact on prognosis and the possible modification of targeted treatment. The investigators will determine the molecular classification in EC by next-generation sequencing (NGS) to detect TP53 and POLE somatic mutations, and immunohistochemical detection of microsatellite instability (MSH2, MLH1, PMS1, PMS2, MSH6, and MSH3) in a cohort of patients with endometrioid-type EC, endometrioid subtype, attended at the Instituto Nacional de Cancerología - Mexico (INCan) and determine its impact on clinical prognosis.

NCT ID: NCT06192017 Recruiting - Endometrium Cancer Clinical Trials

Development of a Molecular Diagnostic Tool for Endometrial Cancer.

Start date: October 18, 2023
Phase:
Study type: Observational [Patient Registry]

WomEC is an in vitro diagnostic test for Endometrial Cancer (EC) based on the detection of the expression level of a combination of 5 proteins in the soluble fraction of a pipelle biopsy specimen. The aim of the study consists in validating WomEC's ELISA test, creating and freezing an algorithm to rule out EC in post-menopausal women with abnormal uterine bleeding (AUB).

NCT ID: NCT06187558 Completed - Endometriosis Clinical Trials

Suspension of the Pelvic and Abdominal Organs During Minimally Invasive Surgery

Start date: March 1, 2019
Phase:
Study type: Observational

The goal of this retrospective observational study is to evaluate the efficacy, safety, and practicality of an organ suspension technique with adjustable tension suture in facilitating minimally invasive gynecologic surgeries at the University Hospital of Cagliari, Italy. The main questions it aims to answer are: - Is the organ suspension technique using adjustable tension suture both cost-effective and practical for minimally invasive gynecologic surgeries? - How safe, effective, and feasible is this suspension technique when applied to patients with benign or malignant gynecological diseases undergoing laparoscopic surgery? Participants in this study underwent laparoscopic surgery involving the organ suspension technique, which includes: - The use of a modified Foley catheter and Polyglactin suture for organ suspension. - The collection of preoperative and postoperative data, such as operation times, blood loss, hospital stay duration, and short-term postoperative complications. This study does not include a comparison group, focusing instead on the direct outcomes and experiences of the participants who underwent the specified surgical technique.

NCT ID: NCT06184867 Recruiting - Breast Cancer Clinical Trials

Choices About Genetic Testing And Learning Your Risk With Smart Technology

CATALYST
Start date: October 26, 2023
Phase: Early Phase 1
Study type: Interventional

The goal of this observational study is to increase genetic education and genetic testing for hereditary cancer risk among cancer survivors. The study objectives are to: 1. Finalize the development and optimize usability of the CATALYST digital intervention (i.e., also known as relational assistant (RA)) 2. Evaluate the feasibility and acceptability of a streamlined cancer genomic care delivery model in cancer survivors. Participants will be randomized to one of two study arms: the RA intervention vs. enhanced usual care (EUC) 3. Assess GC and GT uptake and conduct a process evaluation to measure barriers/facilitators to GC, GT and use of the CATALYST intervention and engagement with the RA.

NCT ID: NCT06180733 Recruiting - Endometrial Cancer Clinical Trials

Neo-adjuvant Pembrolizumab as an Alternative Treatment for MMRd Uterine Cancer

PAM-II
Start date: December 1, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to establish the fraction of patients that achieve a major pathological response (MPR) after 9 cycles of pembrolizumab, with the ultimate aim of informing a follow-up randomized trial. Participants will receive 9 cycles of pembrolizumab before their standard of care hysterectomy.

NCT ID: NCT06172478 Recruiting - Prostate Cancer Clinical Trials

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Start date: February 26, 2024
Phase: Phase 2
Study type: Interventional

This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma [cutaneous/acral], squamous cell carcinomas of the head and neck (SCCHN), and HER2-negative gastric cancerovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, and prostate cancer.

NCT ID: NCT06171789 Recruiting - Ovarian Cancer Clinical Trials

PRO1107 in Patients With Advanced Solid Tumors

Start date: January 29, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a global, open-label, multicenter Phase 1/2 study to evaluate the safety, tolerability, PK, and antitumor activity of PRO1107 in patients with advanced solid tumors. This study consists of 2 parts, Part A: dose escalation and dose level expansion, and Part B: tumor specific expansion.

NCT ID: NCT06171581 Not yet recruiting - Clinical trials for Endometrial Neoplasms

Effect of Stress Ball Use on Anxiety Level During Endometrial Biopsy Procedure

Start date: February 2024
Phase: N/A
Study type: Interventional

The aim of this study is to determine the effect of stress ball application on the anxiety level during the endometrial biopsy procedure. This research is planned as a randomised controlled study. Place and time of the research: The research is planned with patients who will undergo endometrial biopsy procedure in Zonguldak Obstetrics and Gynecology Hospital affiliated to the Ministry of Health. While there are various experimental studies in the literature on the effect of stress ball on anxiety during many painful procedures, there is no study in the literature on the effect of stress ball on anxiety level during endometrial biopsy procedure (Akarsu, Kuş & Akarsu 2021, Genç 2021Nurdina, Anggraini & Novyanda 2022, Srivarsan, Sridevi & Preetha 2021, Yanks et al. 2018,) In this study, it was aimed to evaluate the effect of stress ball application on anxiety level during endometrial biopsy procedure

NCT ID: NCT06170684 Not yet recruiting - Clinical trials for Atypical Endometrial Hyperplasia and Endometrial Cancer

Conservative Treatment for Atypical Endometrial Hyperplasia and Early Endometrial Cancer

Start date: December 2023
Phase:
Study type: Observational

Exploring the efficacy and pregnancy outcomes of conservative treatment for atypical endometrial hyperplasia and endometrial cancer. Study the factors related to predicting treatment efficacy.

NCT ID: NCT06169449 Recruiting - Endometrium Cancer Clinical Trials

Weight Management in Overweight Endometrial Cancer Patients Undergoing Fertility-sparing Treatment

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

In this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups. The test group was given weight management, while the control group was given routine care. Relevant information such as body morphology and composition, glycolipid metabolism, molecular typing and tumor outcomes of the subjects were collected. By evaluating the tumor outcome and changes in glycolipid metabolism indicators, to confirm the effectiveness and safety of weight management for overweight and obese patients with endometrial cancer and treatd with fertility preservation.