Hypoxic Pulmonary Vasoconstriction Pilot Study

Status Completed

Clinical Trial Summary

The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.

Clinical Trial Description

Overall goals of this study are to 1) determine the effects on sildenafil on the heterogeneity perfused blood volume in smokers susceptible to emphysema using dual energy CT 2) utilize pulmonary blood volume heterogeneity as an image-based biomarker to differentiate normal and susceptible smokers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03733470
Study type	Interventional
Source	University of Iowa
Contact
Status	Completed
Phase	Phase 4
Start date	June 29, 2011
Completion date	January 13, 2014

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05825261` - Exploring Novel Biomarkers for Emphysema Detection
Completed	`NCT02999685` - Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients	N/A
Completed	`NCT02914340` - REACH SVS Control Patient Cross-Over Study	N/A
Completed	`NCT02232841` - Electrical Impedance Imaging of Patients on Mechanical Ventilation	N/A
Completed	`NCT02238327` - Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes
Completed	`NCT01615484` - Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	N/A
Withdrawn	`NCT01908933` - Study of the AeriSeal System Treatment in Patients With Advanced Non-Upper Lobe Predominant Heterogeneous Emphysema	Phase 3
Completed	`NCT01476995` - Prognostic Indicators as Provided by the EPIC ClearView	N/A
Completed	`NCT01710449` - Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen	Phase 1
Suspended	`NCT00523094` - Vibration Response Imaging (VRI) in Patients That Are Candidates for Undergoing Pulmonary Operation Procedure	N/A
Completed	`NCT00475007` - Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema	N/A
Recruiting	`NCT00129350` - Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation	Phase 1
Completed	`NCT01953523` - Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions	N/A
Completed	`NCT00000621` - Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)	Phase 2
Completed	`NCT00005292` - Alpha1-antitrypsin Deficiency Registry	N/A
Recruiting	`NCT04537182` - Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema	N/A
Active, not recruiting	`NCT02713347` - Advancing Symptom Alleviation With Palliative Treatment	N/A
Recruiting	`NCT04302272` - STRIVE Post-Market Registry Study
Completed	`NCT04435327` - Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)
Completed	`NCT03636347` - A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.	Phase 2