Emphysema Clinical Trial
Official title:
Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema
Verified date | May 2010 |
Source | Beijing Chao Yang Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | China: Ministry of Health |
Study type | Observational |
This study is to evaluate the expression of biological markers in induced sputum and peripheral blood T lymphocytes of patients with combined pulmonary fibrosis and emphysema (CPFE). The features of CPFE would be observed, including pulmonary function tests and fractional exhaled nitric oxide (FENO).
Status | Completed |
Enrollment | 82 |
Est. completion date | June 2011 |
Est. primary completion date | June 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 50 Years to 90 Years |
Eligibility |
Inclusion Criteria: 1. IPF-alone group: 10 patients meeting the IPF diagnosis criteria without emphysema. 2. CPFE group: 15 patients with CT presentation of concomitant upper-lobe emphysema and lower-lobe fibrosis. 3. Emphysema-alone group: 15 patients with their CT diagnosis of emphysema without fibrosis. 4. Control: 20 healthy sex- and age-matched volunteers including nonsmokers and smokers. None of the healthy volunteers with a history of respiratory diseases. Exclusion Criteria: 1. Age > 90 or < 50 2. Treated with corticosteroids or other immunomodulatory drugs 3. Some known causes of interstitial lung disease such as collagen vascular disease, drug-induced lung disease, occupational disease. 4. An exacerbation in 4 weeks 5. Subjects had a history of allergic diseases. |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
China | Beijing chaoyang hospital-affiliate of captial medical university | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Beijing Chao Yang Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the expression of CXCR3 in blood by flow cytometry and the chemokine IL-4,IFN-?,CXCL9,CXCL10,CXCL11 and CCL17 in sputum and blood | six months | Yes | |
Secondary | pulmonary function tests | six months | Yes | |
Secondary | fractional exhaled nitric oxide (FENO) | six months | Yes |
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