Clinical Trials Logo

Clinical Trial Summary

The main objective for investigators is to determine the prevalence of moderate to severe chronic pain in the adult population 6 months after consultation in the emergency department for acute pain (less than 7 days old) and severe pain assessed at admission and defined as greater than or equal to 6/10 by the numerical pain scale.


Clinical Trial Description

The presence of pain is the most frequent reason for a patient to visit the emergency department. the investigators know that severe acute pain can be a risk factor for developing chronic pain. Chronic pain is a symptom, devoid of biological utility, that persists despite the absence of nociceptive stimulus, even after a reasonable period of time that would have allowed the tissue lesion to heal. It is therefore a public health problem with a negative impact on patients' lives. Chronic pain has been studied in anesthesia and surgery in recent years. In 2006, a study showed the appearance of chronic pain (incidence between 10-50%) in patients who had undergone routine surgery. On the other hand, few studies have looked at the occurrence of chronic pain in patients who came to the emergency department for acute pain. It is in this context that the investigators find it relevant to assess the prevalence of moderate to severe chronic pain after an emergency department consultation for severe acute pain. The physiological mechanisms of pain are better identified and the activation of N-methyl-D-aspartate (NMDA) receptors contributes to the onset of hyperalgesia. These receptors are activated under certain conditions, such as during intense and prolonged pain or exposure to high doses of opioids. In addition, the hyperalgesic effect of opioids is known and widely described in the literature. Finally, in the perioperative period, it is now accepted that the administration of a low dose of ketamine can combat these hyperalgesic effects thanks to its NMDA receptor inhibitory action. This effect may have an impact on pain at six months after surgery. On the basis of these data, it seems relevant to question the prevalence of chronic pain in the course of an emergency department consultation, all the more so in patients with severe initial pain, in whom there is an initial indication for morphine titration, based on the recommendations of the French Society of Emergency Medicine (SFMU). In addition, the investigators need to question the effects of initial analgesia administered in the emergency department for patients with severe acute pain. Is there a link between the use of certain molecules or the combination of molecules on the onset of chronic pain? ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04625374
Study type Observational
Source University Hospital, Grenoble
Contact
Status Completed
Phase
Start date December 5, 2020
Completion date March 1, 2022

See also
  Status Clinical Trial Phase
Completed NCT04021771 - Trial of Simulation-based Mastery Learning to Communicate Diagnostic Uncertainty N/A
Completed NCT05870137 - Assessing Mixed Reality for Emergency Medical Care Delivery in a Simulated Environment N/A
Completed NCT05073406 - Cognition at Altitude in HEMS - Part II N/A
Completed NCT03457272 - Development and Evaluation of a Patient Safety Model N/A
Completed NCT04138446 - Effects of Acute Hypobaric Hypoxia Exposure on Neurocognitive Performance of Pre-hospital Emergency Service Providers N/A
Completed NCT02661607 - Point of Care Echocardiography Versus Chest Radiography for the Assessment of Central Venous Catheter Placement N/A
Recruiting NCT05937763 - ED Adaptive Staffing Study
Completed NCT03848559 - Airway Management With Simulated Microgravity Using a Submerged Model N/A
Completed NCT04328519 - The Charlson Comorbidity Index: Predicting Severity in Emergency Departments
Completed NCT03314480 - REDucing Unnecessary Computed Tomography Imaging for MaxillOfacial INjury
Not yet recruiting NCT06240572 - Development of a Natural Language Processing Tool to Enable Clinical Research in Emergency Medicine
Enrolling by invitation NCT05809648 - A Study to Assess the Accuracy of Magnetocardiography (MCG) to Diagnose True Ischemia in Patients With Chest Pain in the ED
Completed NCT03099915 - Asthma Attack in the Emergency Department : Reasons Of This Attendance
Completed NCT04206566 - Pre-hospital Advanced Airway Management Studying Expedited Routines
Completed NCT03733158 - Flexible Tip Bougie Catheter Intubation N/A
Completed NCT03420027 - Prehospital and Emergency Feasibility of MACOCHA Score Assessment to Predict Difficult Tracheal Intubation
Recruiting NCT03486171 - Tracheal Intubation and Prehospital Emergency Setting
Completed NCT00448331 - Facilitated Referral for Children Screening Positive for Mental Illness Phase 0
Completed NCT04460196 - Healthcare Renunciation During the Confinement Period in Connection With the COVID-19 Epidemic in Adult Emergency Departments
Recruiting NCT06002542 - Mobile Chat Service for Parents of Children in Pediatric Emergency Room N/A