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Emergencies clinical trials

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NCT ID: NCT04293653 Active, not recruiting - Frailty Clinical Trials

Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy

(ProPEL)
Start date: January 21, 2020
Phase: N/A
Study type: Interventional

In the ProPEL study the effect of a protocol designed for elderly patients about to undergo emergency abdominal surgery will be investigated. The protocol addresses issues of both frailty and ceiling-of -care decisions.

NCT ID: NCT04280926 Active, not recruiting - Clinical trials for Acute Coronary Syndrome

Use of High Sensitivity Cardiac Troponin In Ruling Out Emergency Patients With Acute Myocardial Injury and Infarction

SAFETY
Start date: October 13, 2020
Phase:
Study type: Observational

Examine the analytical and clinical performance of Atellica IM TnIH assay for the diagnosis and rule out of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI measurements are obtained on clinical indication.

NCT ID: NCT04235738 Active, not recruiting - Cognitive Frailty Clinical Trials

Cognitive Impairment in Older Emergency Department Users and Associated Adverse Outcomes

Start date: January 17, 2020
Phase:
Study type: Observational

This study examines the prevalence and incidence of older ER users with cognitive impairment (i.e., dementia and/or delirium) using the ER2 item temporal disorientation in older ED users who are participants of the ER2 cohort study database.

NCT ID: NCT04197271 Active, not recruiting - Emergencies Clinical Trials

Management of Acutely Symptomatic Hernia

MASH
Start date: March 3, 2020
Phase:
Study type: Observational

Acutely symptomatic abdominal wall hernia can cause many symptoms and complications. They can be associated with levels of morbidity beyond that seen in emergency laparotomy. There is limited data to guide practice in this field. This observational cohort study will explore variation in practice around assessment, repair and outcomes of hernias treated in the emergency setting.

NCT ID: NCT04170660 Active, not recruiting - Pre-Eclampsia Clinical Trials

Interest of sFlt1/PlGF Ratio at Obstetric Emergencies

AngioCHIC
Start date: November 18, 2019
Phase:
Study type: Observational

In patients with suspected placental vascular disease who do not require hospitalization, the use of the sFlt-1 (Soluble FMS like tyrosin-kinase-1)/PlGF (Placental Growth Factor)/ assay can most likely help teams to define the best possible management.

NCT ID: NCT04163081 Active, not recruiting - Clinical trials for Nicotine Dependence, Cigarettes

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

INITIATE
Start date: April 19, 2022
Phase: N/A
Study type: Interventional

The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED). The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs in Canada offer tobacco-use interventions. In order for ED staff to offer quit smoking support, interventions need to be simple given the realities of the ED environment. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex ED environments.

NCT ID: NCT04144803 Active, not recruiting - Anesthesia Clinical Trials

Brain Oxygenation During Prehospital Anesthesia: an Observational Study

BOPRA
Start date: November 18, 2019
Phase:
Study type: Observational

Brain oxygenation of adult patients undergoing prehospital emergency anesthesia is monitored using noninvasive near-infrared spectroscopy. Patients are afterwards interviewed to define neurological outcome to measure quality of life. The purpose of this study is to reveal the risk factors of prehospital anesthesia related cerebral desaturation events (CDE) and to define the association between CDE and survival, neurological outcome or quality of life.

NCT ID: NCT04109885 Active, not recruiting - Pain Management Clinical Trials

Paracervical Injection for Headache in the Emergency Department

Start date: September 15, 2020
Phase: Phase 2
Study type: Interventional

Headache is one of the most common presenting complaints in the emergency department.1 By the time patients with benign headaches present for treatment in the ED, they often have exhausted non-invasive treatments, and physicians are left with few therapeutic options. The investigators therefore propose to study the use of paracervical injection as a novel approach to managing headache in the emergency department. This procedure has great potential, if efficacious, to provide a safe, rapidly effective, non-sedating treatment for headache that does not involve intravenous line placement and systemic medication administration. To date, there are no published trials that evaluate this technique in this setting. The investigators intend to compare the efficacy of paracervical injection to standard first-line therapy (intravenous prochlorperazine and diphenhydramine) for the treatment of benign headache of any etiology in the emergency department.

NCT ID: NCT04070521 Active, not recruiting - Substance Abuse Clinical Trials

EEG Monitoring in the Emergency Department

Start date: September 6, 2019
Phase:
Study type: Observational

This study seeks to investigate whether drug effects in suspected overdose patients could be identified using the electroencephalogram (EEG). From previous work it is known that different classes of anesthetic drugs have specific "EEG signatures" related to the drug mechanisms. Many of the drugs of abuse that are frequently encountered in overdose patients are similar or identical to anesthetic drugs. The hypothesis for this study is that the EEG could be used to characterize the brain effects of intoxicants using EEG in the ED setting. Such monitoring could one day help clinicians and first responders at the point-of-care make more informed decisions to improve the care of overdose patients.

NCT ID: NCT04048369 Active, not recruiting - Influenza Clinical Trials

Impact of Influenza/RSV PCR Point-of-care Testing in the Emergency Medical Service.

Start date: January 17, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to compare Emergency Department patients who undergo influenza and RSV PCR testing using an FDA-approved point-of-care device (Cepheid Xpert® Xpress Flu/RSV) located in the ED, to patients who undergo influenza and RSV PCR testing at the core laboratory. The principal purpose is to determine if the time spent in the ED is different in the group undergoing POC influenza testing compared to those undergoing laboratory-based influenza testing.