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Emergencies clinical trials

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NCT ID: NCT03840603 Recruiting - Clinical trials for Respiratory Tract Infections

Impact on PCT+ FilmArray RP2 Plus Use in LRTI Suspicion in Emergency Department

PROARRAY
Start date: September 1, 2019
Phase: N/A
Study type: Interventional

The real-time reporting of PCT results along with viral PCR data from the FilmArray® Respiratory Panel 2 plus in conjunction with an antimicrobial stewardship plan will aid in the proper withholding or withdrawing of antibiotics (ATB) when the collective data is indicative of a viral Lower Respiratory Tract Infection (LRTI). The addition of the FilmArray® RP2plus diagnostic test indicating the presence of a viral infection in subjects presenting with respiratory symptoms could improve the confidence to care-providing physicians to withhold prescribing antibiotics.

NCT ID: NCT03818867 Recruiting - Preterm Birth Clinical Trials

Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial

ENCIRCLE
Start date: May 15, 2017
Phase: N/A
Study type: Interventional

Twin pregnancies are at an increased risk of early delivery. One of the reasons for this may be due to a weakened neck of the womb (cervix). There are 2 main ways to manage a weakened cervix in pregnancy. One option is to do nothing (conservative approach). The other is to strengthen the cervix with a stitch (cerclage) to provide extra support. There is no good quality convincing evidence to suggest which of these has better outcomes for mum and babies in twin pregnancies. This trial aims to determine whether securing the weakened cervix with a cerclage will help to prolong the pregnancy and prevent early delivery. Babies who are born early experience multiple complications including lung, brain and learning difficulties. Therefore, the study will also aim to determine whether prolonging the pregnancy by inserting the cerclage reduces the number of babies affected by these problems. In order to carry out a fair study we aim to perform what is known as a randomised controlled trial. We will include in the trial two major groups: (1) women pregnant with twins, who present with a weakened cervix and no signs of infection between 14 and 26 weeks of pregnancy. This will be diagnosed on an internal examination or ultrasound scan, and (2) women pregnant with identical twins complicated by twin-to-twin transfusion syndrome (TTTS) treated by Laser surgery between 16 and 26 weeks in whom a short cervix (<15mm) is identified. TTTS is rare but potentially devastating condition which occurs in about 10-15% of identical twin pregnancies. If left untreated, 80-90% of these babies will die. Overall, best first-line treatment of TTTS is laser surgery. Cervical length is a strong predictor of preterm delivery in these pregnancies. Participants will be allocated randomly into the intervention (cerclage) or control (conservative) group. The procedure to insert the cerclage will be performed under an anaesthetic to minimise discomfort and you will be admitted for 2-3 days following the operation to ensure there are no complications or signs of labour. Women in both groups will be followed up in the same manner until they deliver and the pregnancy outcomes will be compared between the 2 groups to determine which management option is best.

NCT ID: NCT03811990 Recruiting - Depression Clinical Trials

Does a Phone-based Meditation Application Improve Mental Wellness in Emergency Medicine Personnel?

Start date: December 19, 2018
Phase: N/A
Study type: Interventional

Emergency medicine is notorious for its high rate of burnout and mental health issues. The emergency department (ED) is a high paced work environment dealing with life and death issues. Employees in the ED work shift times that are not conducive to a natural circadian rhythm. All of these factors lead to high rates of burnout and overall dissatisfaction with their career choice. These are known downsides of a career in emergency medicine, but little effort is put into addressing this issue in everyday EDs. Cell phones offer an easy and convenient means to participate in meditation. There are multiple evidence-based meditation apps available to cell phone users free of charge. Meditation has been shown to decrease burnout, rates of depression, and rates of anxiety. We hypothesize that weekly use of a meditation-based cell phone application will improve the mental health of emergency department employees as measured on various wellness inventories.

NCT ID: NCT03808896 Recruiting - Clinical trials for Intubation Complication

TCHCCT-Zhong-Xing-Emergency-Department-airway-clincal (TTC)

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

In the previous study on mannekin, the investigators found stylet-assisted lifting of epiglottis is an useful technique on difficult airway (Cormack-Lehane grade IIIa, IIIb) without increasing subjective difficulty. It has no expenses other than the routine intubation process. Recently, the studies have proved that the bougie-assisted laryngoscopy can improve first pass intubation rate in the emergency department. However, bougie is a disposable device and may increased medical expenditure. The investigators will evaluate the safety of bougie and epiglottic lifting technique, as well as the first pass and overall success rate of intubation comparing to traditional video laryngoscopy and direct laryngoscopy.

NCT ID: NCT03786250 Recruiting - Aging Clinical Trials

Comprehensive Geriatric Assessment in an Emergency Department

CGA_ED
Start date: December 1, 2018
Phase:
Study type: Observational

Purpose Frailty and multi-morbidity have been associated with increased pressure on Emergency Departments (ED), higher hospital admissions and more risks for patients arising from the ED stay. The advantages of developing specific attention to frailty in ED have been highlighted. The benefits of these approaches are related to patients but also to organizations. The aim is to present how a Program of Care for Frailty (PCF) in an ED impacts on patient health and flows. Objective is to analyze the clinical impact of Comprehensive Geriatric Care (CGA) in the Emergency Department (ED) and on patient flows Setting: A tertiary, teaching, 550-bed urban hospital, with 80,000 adult patients/year ED attendances (43%≥65 years). Two periods are compared: First period (before CGA implantation) del 01/04/2016 - 15/04/2016 and second period (after) 01/04/2017 - 15/04/2017

NCT ID: NCT03784573 Recruiting - Anxiety Clinical Trials

Canine-Assisted Anxiety Reduction In Emergency Care

CANINE III
Start date: January 7, 2019
Phase: N/A
Study type: Interventional

Compare the effect of a single exposure to a therapy dog and handler within the pediatric emergency department patient with anxiety by measuring the change in patient perception of anxiety before and after dog exposure using the FACES scale. We will also measure galvanic skin response (resistance to electrical current).

NCT ID: NCT03769740 Recruiting - Cardiac Arrest Clinical Trials

Cerebral Oximetry and NIRS in Cardiac Arrest Patients

Start date: May 1, 2009
Phase:
Study type: Observational

This is an observational study to define the role and future applications of cerebral oximetry in cardiac arrest patients.

NCT ID: NCT03765567 Recruiting - Open Fracture Clinical Trials

Placement of Antibiotic Powder in Wounds During the Emergency Room

POWDER
Start date: October 5, 2020
Phase: Phase 4
Study type: Interventional

This is the first prospective controlled study to determine whether the topical application of vancomycin powder reduces infection-related complications when applied to open fracture injuries in the acute emergency department setting.

NCT ID: NCT03765060 Recruiting - Clinical trials for Abdominal Wall Defect

The Efficacy and Security of the Small Stitch Technique in Emergency Surgery

STCU
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the abdominal closure technique in emergency surgery. Half of participants will be perform the classic Large Stitch technique, while the other half will undergo the Small Stitch technique.

NCT ID: NCT03717350 Recruiting - Sepsis Clinical Trials

suPAR to Guide Antibiotics in Emergency Department

Start date: October 27, 2018
Phase: Phase 2/Phase 3
Study type: Interventional

The aim of the current study is to evaluate suPAR - guided medical intervention, consisting of early antibiotic administration at the emergency room for presumed infection and sepsis and evaluate the impact of this intervention to the patients' final outcome. Since the traditionally used biomarkers (PCT, CRP) and scores (SOFA score) for early recognition of severity of infection fail to achieve maximum accuracy in all cases, suPAR levels are assessed as a probably better prognostic rule for early recognition of severe infections. The primary study endpoint will be the comparative efficacy of the early suPAR-guided administration of antibiotics versus standard practice on 28-day mortality.