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Ehlers-Danlos Syndrome clinical trials

View clinical trials related to Ehlers-Danlos Syndrome.

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NCT ID: NCT05757960 Recruiting - Clinical trials for Hypermobile Ehlers-Danlos Syndrome

TMD-specific Physiotherapy in hEDS Patients Individuals With Hypermobile Ehlers-Danlos Syndrome

Start date: February 2, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to analyze the effects of strictly defined physiotherapy in patients temporomandibular dysfunction (TMD) and hypermobile Ehlers-Danlos Syndrome (hEDS). Patients will be clinically examined before starting physiotherapy and fill in the questionnaires. Subsequently, it will be followed up whether changes occur as a result of physiotherapy. This study is a pilot study and is intended to be hypothesis generating in nature. Based on the resulting hypothesis, it will be verified by a study with a control group.

NCT ID: NCT05720923 Recruiting - Rare Diseases Clinical Trials

Analysis of Muscular Properties in Patients With MFS and EDS

MUSCLE
Start date: February 15, 2023
Phase:
Study type: Observational

The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS). the main questions it aims to answer are: - To assess the ability to develop muscle strength; - Muscle and tendon morphology involved in muscle contractions/relaxation; - Neuromuscular functionality. Participants will be take part in the study by performing a test for the assessment of the neuromuscular activity (voluntary muscle contractions) and undergoing a muscle ultrasound for the study of muscles and tendons. Researchers will compare the two groups with a control group to see potential differences in the morphological and neuromuscular structures of syndromic patients.

NCT ID: NCT05712564 Completed - Depression Clinical Trials

Fatigue, Depressive Disorders and Insomnia in Adult Patients With Marfan Syndrome and Ehlers-Danlos Syndrome: Survey

FAMED
Start date: January 9, 2023
Phase:
Study type: Observational

The goal of this observational study is to describe and assess the presence of perceived fatigue in subjects with MFS and EDS. the main question it aims to answer through the FSS instrument is: - The relationship of fatigue with physical and psychological characteristics, the presence of depressive disorders and insomnia.

NCT ID: NCT05685199 Recruiting - Clinical trials for Heavy Menstrual Bleeding

Identifying the Determinants of Bleeding and Hypermobility in Patients With Heavy Menstrual Bleeding

Start date: May 10, 2024
Phase:
Study type: Observational

In this study, researchers want to learn about the connection between heavy bleeding issues and joint hypermobility (loose joints). They want to know if these issues may indicate other connective tissue problems in girls and women with heavy menstrual bleeding who do not have a known cause. Primary Objective - Compare the severity of heavy menstrual bleeding (HMB) in women with and without Generalized joint Hypermobility Syndrome Disorder/hypermobile Ehlers-Danlos Syndrome (G-HSD/hEDS) using bleeding scores. Secondary Objectives - Compare the frequency of co-morbidities in women with and without G-HSD/hEDS.

NCT ID: NCT05633225 Completed - Clinical trials for Hypermobile Ehlers-Danlos Syndrome

Central Sensitization and Physical Activity in Adolescents With HSD/hEDS

Start date: November 25, 2022
Phase:
Study type: Observational

Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear. The goal of this study is to better understand pain and its impact on function in the daily activities of adolescents with Hypermobility Spectrum Disorder and/or hypermobile Ehlers-Danlos Syndrome. This study will explore the presence of the pain sensitivity status after physical exercise as well as movement behaviour in adolescents with HSD/hEDS compared to a healthy control group.

NCT ID: NCT05603741 Active, not recruiting - Anesthesia, Local Clinical Trials

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Start date: November 10, 2022
Phase: Phase 4
Study type: Interventional

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

NCT ID: NCT05561270 Recruiting - Pain, Chronic Clinical Trials

Light Exposure on Pain in Hypermobile Ehlers-Danlos Syndrome

LEEDS
Start date: November 21, 2022
Phase: N/A
Study type: Interventional

Chronic pain is a major complaint among many individuals living with hypermobile Ehlers Danlos Syndrome (hEDS) and may have a severe impact on quality of life and activities of daily living. Given the complexity of the disease's pathophysiology, effective treatments are limited. This investigation will examine the impacts of green light exposure on subject-reported pain severity and symptoms. Knowing whether this intervention can improve pain and quality of life in this population may offer valuable guidance to clinicians who treat hEDS patients and to hEDS patients themselves.

NCT ID: NCT05516043 Completed - Clinical trials for Peripheral Arterial Disease

Safety and Performance of POLYTHESE® Vascular Prosthesis

Start date: July 7, 2021
Phase:
Study type: Observational

POLYTHESE® study is a retrospective, observational, multicentre, case series which examine short and long-term outcomes of using POLYTHESE®. This study will be done on Real World Data to describe the safety and performance of the device. PMCF Study.

NCT ID: NCT05463679 Suspended - Clinical trials for Vascular Ehlers-Danlos Syndrome

Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.

PREVEnt
Start date: January 2025
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy of enzastaurin compared to placebo in preventing arterial events (rupture, dissection, pseudoaneurysm, carotid-cavernous sinus fistula, or aneurysm, fatal or not) leading to intervention or mortality attributable to an arterial event in patients with vEDS confirmed with pathogenic heterozygous COL3A1 gene mutations predicted to derive a mutant protein.

NCT ID: NCT05434728 Enrolling by invitation - Clinical trials for Ehlers-Danlos Syndrome

Characterization of Bleeding Disorders in EDS

Start date: November 1, 2022
Phase:
Study type: Observational

Ehlers-Danlos Syndrome (EDS) is a disease that weakens the connective tissues (i.e. tendons and ligaments) in the human body. EDS can make the joints loose and alter skin and wound healing. It can also weaken blood vessels and organs. Many EDS patients are referred for investigation of bleeding symptoms. Although most patients will have mild symptoms such as bruising, many will experience significant bleeding that can be life-threatening. The physiological reason behind this has not been identified and therefore, treating this is challenging. In addition, patients with EDS frequently require major surgery due to complications from their connective tissue disease. These surgery carries a significant risk of catastrophic bleeding which is further magnified in this group of patients. The specific reason of clinical bleeding in patients with EDS is likely multifactorial, including skin and blood vessel fragility leading to increased bruising and poor wound healing, coagulopathies related to factor deficiency, acquired vonWillebrand disease (VWD), and notable platelet dysfunction. Despite compelling preliminary evidence, there is limited data on the diagnosis and management of platelet dysfunction in EDS patients. Therefore, in this study we will characterize hemostasis, the medical term which refers to the process of stopping blood flow, across the three most common subtypes of EDS.we will also determine the burden of illness of pathologic bleeding in patients with Ehlers-Danlos Syndrome (EDS) using validated patient reported tools.