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Ehlers-Danlos Syndrome clinical trials

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NCT ID: NCT05463679 Suspended - Clinical trials for Vascular Ehlers-Danlos Syndrome

Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.

PREVEnt
Start date: January 2025
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the efficacy of enzastaurin compared to placebo in preventing arterial events (rupture, dissection, pseudoaneurysm, carotid-cavernous sinus fistula, or aneurysm, fatal or not) leading to intervention or mortality attributable to an arterial event in patients with vEDS confirmed with pathogenic heterozygous COL3A1 gene mutations predicted to derive a mutant protein.