Effect of Resveratrol and Curcumin on Inflammation Clinical Trial
Official title:
The Effect of Resveratrol and Curcumin on Postprandial Inflammation in Men and Postmenopausal Women
The general objective of this project is to investigate the acute effect of consuming a
dietary supplement combining resveratrol and curcumin on the inflammatory response following
the consumption of a high-fat meal in healthy subjects with slightly elevated waist
circumference.
The study will be undertaken according to a double-blind, cross over, randomized, placebo
controlled design and will be conducted at the Institute of Nutrition and Functional Foods
(INAF) of Laval University. The study will involve a total of 20 healthy subjects (10 men
and 10 women. Included subjects will undergo an 6-hour oral fat tolerance, on two separate
occasions (one time following dietary supplement consumption and one time following
consumption of a placebo). The two test days will be separated by maximum of two weeks. The
outcomes are the changes in the plasma levels of inflammatory cytokines in their gene
expression.
There is increasing evidence showing that inflammation is implicated in the pathogenesis of
numerous chronic conditions and cardiovascular disease (CVD). Also, high-fat meals have been
shown to induce postprandial oxidative stress and inflammation. Polyphenols are compounds
found ubiquitously in plants and are known to regulate many processes like plant growth,
reproduction, seed germination as well as resistance to pathogens and predators. They are
present in fruits and vegetables and exhibit favorable physiological effects that even if
they remain not fully understood, still allow the classification of phenolic compounds as
antiinflammatory molecules.
Resveratrol is a polyphenol that is found in berries, grapes and red wine among others.
Interest for resveratrol as a health-promoting molecule has flourished in recent years as it
has been shown to prevent co-morbidities associated with diabetes and CVD. Evidence of the
physiological benefits of resveratrol in humans is somewhat limited, but nonetheless
supports an antiinflammatory action.
There is also an increasing body of evidence supporting the role of curcumin, a polyphenol
from the curcuminoid family, as a modulator of the inflammatory pathway.These observations
underline the anti-inflammatory potential of curcumin and how it may serve in the prevention
and treatment of chronic conditions like diabetes and CVD.
The general objective of this project is to investigate the acute effect of consuming
dietary supplement combining resveratrol and curcumin on the inflammatory response following
the consumption of a high-fat meal in healthy individuals with slightly elevated waist
girth.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention