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Clinical Trial Summary

A study to evaluate the effectiveness and safety of levosimendan compared with placebo in subjects with severe aortic stenosis and heart failure undergoing transcatheter aortic valve replacement


Clinical Trial Description

The number of subjects undergoing transcatheter aortic valve replacement to treat aortic stenosis have been increasing in recent decades. Levosimendan, an innovative inotrope, is powerfully evidenced to have the function to improve cardiac output and hemodynamic parameters. However, there is no specified study concentrated on the role of Levosimendan in surgical procedure such as transcathter aortic intervention. This double-blind, randomized, placebo-controlled study is aimed to investigate the effectiveness and safety of Levosimendan in adults having severe aortic stenosis combined with heart failure undergoing transcatheter aortic valve replacement. Therefore, the purpose of this trial is to explore whether the improvement of cardiac and renal performance can be rendered by intra-operative Levosimendan infusion. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04573049
Study type Interventional
Source China National Center for Cardiovascular Diseases
Contact Jianhui Wang, MD
Phone 010-88398082
Email stewenwang@sina.com
Status Recruiting
Phase Phase 4
Start date September 1, 2020
Completion date December 30, 2022

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