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Eating Behavior clinical trials

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NCT ID: NCT05456516 Recruiting - Obesity, Childhood Clinical Trials

Study of Brain, Reward, and Kids' Eating

BRAKE
Start date: January 10, 2023
Phase: N/A
Study type: Interventional

Children from rural communities are at greater risk for obesity than children from more urban communities. However, some children are resilient to obesity despite greater exposure to obesogenic influences in rural communities (e.g., fewer community-level physical activity or healthy eating resources). Identifying factors that promote this resiliency could inform obesity prevention. Eating habits are learned through reinforcement (e.g., hedonic, familial environment), the process through which environmental food cues become valued and influence behavior. Therefore, understanding individual differences in reinforcement learning is essential to uncovering the causes of obesity. Preclinical models have identified two reinforcement learning phenotypes that may have translational importance for understanding excess consumption in humans: 1) goal-tracking-environmental cues have predictive value; and 2) sign-tracking-environmental cues have predictive and hedonic value (i.e., incentive salience). Sign-tracking is associated with poorer attentional control, greater impulsivity, and lower prefrontal cortex (PFC) engagement in response to reward cues. This parallels neurocognitive deficits observed in pediatric obesity (i.e., worse impulsivity, lower PFC food cue reactivity). The proposed research aims to determine if reinforcement learning phenotype (i.e., sign- and goal-tracking) is 1) associated with adiposity due to its influence on neural food cue reactivity and 2) associated with reward-driven overconsumption and meal intake due to its influence on eating behaviors. The investigators hypothesize that goal-tracking will promote resiliency to obesity due to: 1) reduced attribution of incentive salience and greater PFC engagement to food cues; and 2) reduced reward-driven overconsumption. Finally, the investigators hypothesize reinforcement learning phenotype will be associated due to its influence on eating behaviors associated with overconsumption (e.g., larger bites, faster bite rat and eating sped). To test this hypothesis, the investigators will enroll 76, 8-9-year-old children, half with healthy weight and half with obesity based on Centers for Disease Control definitions. Methods will include computer tasks to assess reinforcement learning, dual x-ray absorptiometry to assess adiposity, and neural food cue reactivity from functional near-infrared spectroscopy (fNIRS).

NCT ID: NCT05358899 Recruiting - Schizophrenia Clinical Trials

Accelerated cTBS on Metabolic Dysfunction in People With Schizophrenia

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

cTBS is a promising novel intervention, which has strong potential on moderating disease syndrome. However, the most effective pattern of the cTBS is still under debate. Therefore, the investigators designed this randomized controlled clinical trial to evaluate the efficacy and safety of accelerated cTBS, with 1800 stimulation per session, on intervention to metabolic side effects in individuals with schizophrenia.

NCT ID: NCT05038033 Recruiting - Obesity Clinical Trials

Addressing Anxiety and Stress for Healthier Eating in Teens

ASSET
Start date: February 22, 2021
Phase: N/A
Study type: Interventional

Project ASSET will explore the preliminary efficacy of interpersonal therapy, when compared with cognitive behavioral therapy, for reducing anxiety symptoms, preventing excess weight gain, and reducing cardio-metabolic risk in adolescent girls with above-average weight and elevated anxiety. As a pilot for a larger multi-site study, this trial will also test multi-site feasibility, acceptability, and intervention fidelity.

NCT ID: NCT04847843 Recruiting - Obesity Clinical Trials

Eating Mindfully to Prevent Weight Regain

EMPWR
Start date: June 16, 2021
Phase: N/A
Study type: Interventional

The overall objective of this study is to evaluate the efficacy of a mindfulness-based intervention to prevent weight regain in weight-reduced adults.

NCT ID: NCT04838249 Recruiting - Eating Behavior Clinical Trials

Effects of Cross-sex Hormone Therapy on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System

HHS
Start date: May 5, 2021
Phase:
Study type: Observational

Current study aims to characterize five highly interconnected physiological systems in patients undergoing cross-sex hormone therapy - namely glucose and lipid metabolism, energy balance, eating behavior, functional brain networks involved in the regulation of eating behavior and the cardiovascular system - to gain novel insights into the effects of sex hormones on the human body. Gathered information will help to identify pathophysiological mechanisms for the development of overeating/obesity, insulin resistance, and cardiovascular disease. Secondarily, the relationships between the gut and oral microbiomes and metabolomes and circulating bacterial signatures will be investigated in relation to the other pervasive physiological systems. Current study is an observational study. The decision if the patient's request for cross-sex hormone therapy can complied with (i.e., if cross-sex hormone therapy is medically indicated) is made prior to the first contact with the study center and with the outpatients clinic for Endocrinology at the University Hospital in Leipzig. Decision ifor treatment is made according to national and international guidelines. Treatment of study participants with testosterone and estradiol/antiandrogens is not affected by the study. During the course of the study no invasive interventions are being performed.

NCT ID: NCT04723264 Recruiting - Eating Behavior Clinical Trials

The Development of Eating Behavior in Infancy: Associations With Behavior, Diet, and Growth at School Age

Start date: April 28, 2021
Phase: N/A
Study type: Interventional

This study will examine children's eating behavior. The study will enroll approximately 400 participants (200 child/parent pairs). At certain time points, participants will engage in activities involving the presentation of food and the observation of behavioral responses to these presentations, as well as the completion of questionnaires

NCT ID: NCT04633681 Recruiting - Eating Behavior Clinical Trials

Impact of Sweeteners on Behaviour, Physiology & Health

SWEET-WP2-P2
Start date: April 1, 2021
Phase: N/A
Study type: Interventional

This study aims to evaluate the acute (1-day) and repeated (2-week) effects of combinations of Sweeteners & Sweetness Enhancer blends on metabolic, sensory, neuro-behavioural and microbiota-mediated processes involved in satiety, consumer preferences and health.

NCT ID: NCT04526743 Recruiting - Mental Health Issue Clinical Trials

Eating Behavior and Weight Trajectory After Bariatric Surgery

Regain_SEEN
Start date: September 1, 2019
Phase:
Study type: Observational

Studying the mechanisms of weight regain (WR) may provide much needed insight into sustained obesity management. The aim of this five-year, prospective, multicenter study is to evaluate the association among eating patterns (specifically maladaptive behaviors), certain psychological variables and weight trajectory in the short- and long-term after bariatric surgery (BS). The study will include 2 groups: 1.- Candidates to primary BS undergoing laparoscopic gastric bypass (LGBP) or laparoscopic sleeve gastrectomy (LSG) from September 2020 to September 2021. This group will be evaluated prior to surgery, at 4 months, 1 year, 3 years and 5 years after BS, and 2.- a control group of subjects with obesity not candidates to BS matched with the intervention group for age, sex and BMI prior to BS. They will be evaluated once. The primary variable will be: body weight: total weight lost (%), excess weight lost (%), total weight regained (%), excess of weight regain (%). Information regarding the psychological and behavioral variables will be collected using questionnaires that have been validated in our setting and will be completed by the patients themselves online.

NCT ID: NCT04468672 Recruiting - Eating Behavior Clinical Trials

Eating Behaviors in Shift Workers

Start date: December 14, 2020
Phase: N/A
Study type: Interventional

This study will compare eating behaviors and measures of hunger and fullness between day and night workers in order to better understand why night workers are at increased risk for obesity and related diseases.

NCT ID: NCT04248478 Recruiting - Fibromyalgia Clinical Trials

Eating Behaviours in Female Patients With Fibromyalgia

Start date: January 29, 2020
Phase:
Study type: Observational

The Relationship Between Eating Behaviours and Health Status of Female Patients with Fibromyalgia