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Dyslipidemia clinical trials

View clinical trials related to Dyslipidemia.

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NCT ID: NCT03019263 Completed - Dyslipidemia Clinical Trials

Berberine, Chlorogenic Acid and Tocotrienols in Menopause-associated Dyslipidemia

Start date: March 31, 2017
Phase: N/A
Study type: Interventional

Menopause is usually associated with an increase in body weight, a change in body composition and fat distribution and a large number of cardio-metabolic changes, such as hypertension, reduction of insulin-sensitivity and dyslipidaemia. The first-line strategy for these complications is the modification of dietary habits and lifestyle in terms of physical activity. Besides, there is also a growing interest in complementary therapies (i.e. nutraceuticals) that can be used alone or in combination to achieve more consistent results. In this context, preliminary evidence supports the potential role of some compounds of vegetal origin such as berberine, chlorogenic acid and tocotrienols. However, in support of their use, the evidence from good quality trials is limited.

NCT ID: NCT02993120 Completed - Dyslipidemia Clinical Trials

Getting to an Improved Understanding of Low-Density Lipoprotein Cholesterol and Dyslipidemia Management (GOULD) a Registry of High Cardiovascular Risk Subjects in the United States

Start date: December 6, 2016
Phase:
Study type: Observational

This is a multicenter observational cohort study with both retrospective and prospective data collection components in subjects with ASCVD. The purpose of this study is to better understand cholesterol treatment patterns in the context of a changing landscape in subjects with ASCVD.

NCT ID: NCT02982408 Completed - Clinical trials for Type 2 Diabetes Mellitus

Impact of Overfeeding and Following Exercise Training in Individuals With and Without Increased Risk of Type 2 Diabetes

Start date: August 2016
Phase: N/A
Study type: Interventional

Low birth weight (LBW), a marker of impaired fetal growth is an independent and strong risk factor for type 2 diabetes (T2D). A western lifestyle characterized by a surplus of calories, and/or a low physical activity level, associated with increased fat storage and altered lipid metabolism plays a central role in the pathogenesis of insulin resistance and T2D. Using state-of-the-art large-scale integrative physiology studies combined with basic studies of adipose and muscle tissue stem cell functions, the investigators aim to determine if LBW individuals exhibit decreased subcutaneous adipose tissue expandability, postprandial hyperlipidaemia and ectopic fat accumulation when exposed to 4 weeks of carbohydrate overfeeding. The investigators will subsequently examine if exercise training can revert and/or minimize the deleterious effects of carbohydrate overfeeding in a possibly birth weight differential manner.

NCT ID: NCT02956590 Completed - Obesity Clinical Trials

Dyslipidemia of Obesity Intervention in Teens

DO IT!
Start date: May 1, 2018
Phase: Phase 3
Study type: Interventional

This trial of pitavastatin will determine efficacy and safety in this high risk population and provide evidence for clinicians to target this treatable risk factor to achieve an impact on early atherosclerosis, and potentially achieve primary prevention of adult cardiovascular disease.

NCT ID: NCT02947620 Completed - Dyslipidemia Clinical Trials

Metformin/Atorvastatin Combination Therapy in Subjects With Type II Diabetes and Dyslipidemia (Phase 3)

Start date: August 2015
Phase: Phase 3
Study type: Interventional

A Multi-center, Randomized, double-blind, active-controlled, phase 3 trial to evaluate the safety and efficacy of Metformin/Atorvastatin in subjects with Type II Diabetes and dyslipidemia.

NCT ID: NCT02938091 Completed - Dyslipidemia Clinical Trials

Dietary Modulation of Hepatic Lipase (LIPC) -514 C/T Variant Associations With Lipids and Glucose

Start date: January 2008
Phase: N/A
Study type: Interventional

The investigators evaluated dietary modulation of LIPC rs1800588 (-514 C/T) for lipids and glucose using a randomized cross-over design comparing a high-fat Western diet and a low-fat traditional Hispanic diet in Caribbean Hispanics (n=42; 4 weeks/phase).

NCT ID: NCT02931292 Completed - Obesity Clinical Trials

A Decade of Sleeve Gastrectomy: Analysis of Short and Long-term Outcome of 562 Patients

SG
Start date: June 2005
Phase: N/A
Study type: Observational

Obesity is a chronic disease and its treatment requires close follow-up to accurately assess the efficacy and durability of any treatment strategy. It is widely accepted that bariatric surgery patients require lifetime follow-up to assess for weight loss, co-morbidity changes, and nutritional deficiencies. The study objective was to ascertain efficacy of weight loss and complication rates in 562 consecutive cases of laparoscopic sleeve gastrectomy (LSG) in a single surgeon practice.

NCT ID: NCT02881658 Completed - Dyslipidemia Clinical Trials

The Effect of 3-Week Consumption of Soya Beverage Enriched With Plant Sterols on Serum LDL-C

Start date: May 2016
Phase: N/A
Study type: Interventional

This is a local, single-center, two-arm, randomized, double-blind, placebo-controlled clinical trial that examines the LDL-C-lowering effect of the consumption of a soya beverage enriched with plant sterol for 3 weeks. This study also examines if there is other health-benefits by consuming the plant sterols fortified soya beverage in terms of serum total triglyceride, total and HDL cholesterol, other cardiometabolic risk factors and musculoskeletal-related traits including handgrip strength, gait speed, peak expiratory flow rate, bio-impedance and body balance.

NCT ID: NCT02867813 Completed - Dyslipidemia Clinical Trials

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk Open-label Extension

FOURIER OLE
Start date: September 2, 2016
Phase: Phase 3
Study type: Interventional

The primary clinical hypothesis is that long-term exposure of evolocumab will be safe and well tolerated in subjects with clinically evident atherosclerotic cardiovascular disease (CVD).

NCT ID: NCT02835651 Completed - Dyslipidemia Clinical Trials

Saturated Fatty Acids and HDL Metabolism

Start date: April 14, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether palmitic acid (C16:0) and stearic acid (C18:0) have different effects on HDL metabolism during the fasted state.