Blood Flow in Individuals With Down Syndrome

Status Terminated

Clinical Trial Summary

This study focuses on physiological explanations of difficulties with physical activity and exercise in individuals with Down syndrome, by non-invasively examining cardiac output and the regulation of blood flow to working muscles during exercise.

Clinical Trial Description

Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption. Peak oxygen consumption is very low in individuals with Down syndrome, the most prevalent genetic cause of intellectual disability. Previous research suggests individuals with Down syndrome may experience a double disadvantage when they are exercising: they may not be able to increase cardiac output sufficiently and they may not be able to allocate adequate blood flow to the working muscles.

The aim of this research study is therefore to determine the impact of limitations in central and peripheral regulation of blood flow on work capacity in individuals with DS. The results of this project will aid our understanding of the underlying mechanisms and determine the potential to improve health across the lifespan of individuals with Down syndrome by tailoring exercise interventions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03590665
Study type	Interventional
Source	University of Illinois at Chicago
Contact
Status	Terminated
Phase	N/A
Start date	March 1, 2018
Completion date	May 8, 2019

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