Down Syndrome Clinical Trial
Official title:
Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model
This study may provide information that may serve as the foundation for a larger research study to address issues regarding the causes, diagnosis, and treatment of osteoporosis in the Down syndrome patient population.
Osteoporosis is responsible for more than 1.5 million fractures and $14 billion in medical
care costs annually (U.S Dept of Health and Human Services data, 2006). Down syndrome is an
independent risk factor for osteopenia/osteoporosis. Increases in life expectancy as well as
costly morbidity following fracture are reasons for further investigation of osteoporosis
and prevention in this population. Etiology for low bone density is presently unknown in
this population but may be related to unique genes on chromosome 21 which alter the
biochemistry of bone metabolism or change the gonadal, thyroid and parathyroid function to
alter bone formation and/or resorption. There are no published data on the measurement of
bone turnover markers in the Down syndrome population; therefore we will measure and accrue
this information and compare to our Ts65Dn data, as described later in this protocol.
This pilot study will serve as the foundation for a larger translational research grant
which will address multiple issues regarding the pathogenesis, diagnosis and treatment of
osteoporosis in the Down syndrome patient population and the Down syndrome mouse model
(Ts65Dn). The data has the potential to improve our fundamental understanding of
osteoporosis pathogenesis and treatment in the Down syndrome patient with potential
applications to treatment in the general population.
;
Intervention Model: Single Group Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04854122 -
Blood Flow Regulation in Individuals With Down Syndrome - Training Study
|
N/A | |
| Completed |
NCT04020302 -
Self-Monitoring Shopping Intervention
|
N/A | |
| Recruiting |
NCT01950624 -
DS-Connect {TM}: The Down Syndrome Registry
|
||
| Completed |
NCT04751136 -
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome
|
Phase 2 | |
| Completed |
NCT04767412 -
Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial
|
N/A | |
| Completed |
NCT04536506 -
Bobath and Vojta Therapy for DS
|
N/A | |
| Not yet recruiting |
NCT04037579 -
Protocol for a Non-randomized Survey in Down Syndrome People Who Practice Sports. Self and Observers´ Perception.
|
||
| Completed |
NCT02882698 -
Performance Analysis in Down Syndrome on Mobile Phone
|
N/A | |
| Completed |
NCT01791725 -
A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia
|
Phase 2 | |
| Unknown status |
NCT01975545 -
Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21
|
Phase 2 | |
| Completed |
NCT01808508 -
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
|
N/A | |
| Terminated |
NCT00754052 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
|
Phase 3 | |
| Terminated |
NCT00754013 -
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
|
Phase 3 | |
| Completed |
NCT01256112 -
Parent Supported Weight Reduction in Down Syndrome
|
N/A | |
| Completed |
NCT01313325 -
Hippotherapy to Improve the Balance of Children With Movement Disorders
|
N/A | |
| Completed |
NCT01594346 -
Multicenter Vitamin E Trial in Aging Persons With Down Syndrome
|
Phase 3 | |
| Completed |
NCT05343468 -
Life Skills Improved in Children With Down Syndrome After Using Assistive Technology
|
N/A | |
| Suspended |
NCT05755464 -
Evaluation of Patients With Down Syndrome Compliance to Dental Therapy
|
||
| Recruiting |
NCT04022460 -
Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD)
|
||
| Completed |
NCT04818437 -
Effect of Core Stability Exercises and Balance Training in Postural Control Among Down Syndrome
|
N/A |