Dementia Clinical Trial
Official title:
Regional Cerebral Utilization of Glucose in Patients With a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical basal ganglia disorders. These studies include repeated assessments of neuropsychological and brain anatomical and metabolic function in subjects with these important and possibly related brain disorders.
Objective
To continue the cross-sectional and longitudinal studies performed by the Cognitive
Neuroscience Section of NINDS on the neuroanatomy, cerebral metabolism, neuropsychology, and
genetics of frontotemporal dementia, corticobasal syndrome, and related brain disorders.
Study population
Frontal lobe dementias and atypical basal ganglia disorders including frontotemporal
dementia, corticobasal syndrome, and related brain disorders.
Design
A cross-sectional assessment of neuropsychological, brain anatomical and metabolic function,
and genetic measures in subjects with these disorders.
Outcome measures
MRI, FDG-PET, neuropsychological and clinical tests, genetics, and neuropathology.
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