Disorientation as to People, Time and Place Clinical Trial
Official title:
Proposal to Examine the Effect of Fecal Transplantation on Obesity.
The investigators propose to transplant feces from thin, disease-free donors into obese
patients undergoing colonoscopy for screening for colorectal carcinoma.
The investigators will obtain feces from healthy donors with a BMI of between 21-24. The
investigators will perform colonoscopy on healthy patients with a BMI of 30-40 kg/m2 who
have a clear indication for a screening examination.
All patients will undergo a screening colonoscopy and will be allocated to receive either
250 ml of diluted fecal material prepared from a screened donor, or an equivalent volume of
normal saline (sham transplantation).
The patients will be reviewed at 1 3 6 and 12 months. At this time note will be made of
their weight, BMI and waist circumference. In addition note will be made of their fasting
glucose and lipid profile.
We propose to transplant feces from thin, disease-free donors into obese patients undergoing
colonoscopy for screening for colorectal carcinoma.
We will obtain feces from healthy donors with a BMI of between 21-24, in accordance with the
Protocol that was approved by the Israel Ministry of Health. The stool sample will be
prepared as detailed below :
We will perform colonoscopy on healthy patients with a BMI of 30-40 kg/m2 who have a clear
indication for a screening examination. These will be people who are above the age of 50 who
have not had a screening colonoscopy in the last 10 years, or those with a family history of
carcinoma of the colon who are over the age of 40 years.
All patients will undergo a screening colonoscopy and will be allocated to receive either
250 ml of diluted fecal material prepared from a screened donor, or an equivalent volume of
normal saline (sham transplantation). The material will be injected in the amount of 50 ml
at five locations- the terminal ileum (or the cecum if the terminal ileum cannot be
intubated), ascending colon, transverse colon, descending colon and sigmoid colon- during
withdrawal of the colonoscope from the cecum. The stool will not be delivered to the
endoscopy suite until the patient is sedated and only the endoscopist performing the
procedure will know what treatment arm the patient is in.
In addition, all patients participating in the study will receive standard advice regarding
weight loss and physical activity (at least 90 minutes of walking for week) from a staff
dietitian.
Stool samples will be obtained from the donor( from the stool donated for transplantation)
and the patients at baseline (prior to transplantation), 1 month and 12 months and frozen at
-80 C for high throughput analysis by standard techniques.
The patients will be reviewed at 1 3 6 and 12 months. At this time note will be made of
their weight, BMI and waist circumference. In addition note will be made of their fasting
glucose and lipid profile.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment