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Confusion clinical trials

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NCT ID: NCT06236815 Not yet recruiting - Clinical trials for Impairment, Cognitive

High Confusion: Cannabis & Driving

Start date: June 2024
Phase: Early Phase 1
Study type: Interventional

This study is being done to assess the feasibility of administrating Δ9-THC and Δ8-THC isolates and simultaneously adopting several data harmonization measures to generate uniquely translatable data. This project aims to (1) evaluate the feasibility and acceptability of administering ∆9-THC and Δ8-THC isolates using standardized cannabis dosing units to quantify ∆9-THC and Δ8-THC pharmacokinetics; and (2) evaluate the feasibility and acceptability of adopting standardized impairment detection methods and driving performance definitions and measures on quantifying ∆9-THC and Δ8-THC driving impairment compared to a placebo.

NCT ID: NCT06177847 Not yet recruiting - Anesthesia Clinical Trials

Efficacy of BIS Monitoring in Deep Hypnotic State

Start date: December 15, 2023
Phase: N/A
Study type: Interventional

Determining the efficacy of the BIS monitor in monitoring deep hypnotic states as well as intra- and post-operative outcomes in neurosurgery patients

NCT ID: NCT06176625 Active, not recruiting - Delirium Clinical Trials

Sight and Hearing Investigation Into Effects on Delirium

SHIELD
Start date: January 11, 2023
Phase: N/A
Study type: Interventional

The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: - Are hearing and vision loss related to increased risk of having delirium? - Do hearing and vision loss contribute to more severe delirium? - Do sensory loss and/or delirium affect patient satisfaction with hospital care? Participants will be asked to: - answer delirium screening questions, - undergo hearing & vision screenings, and - complete questionnaires about the hospital stay. The second part of this study is a clinical trial. Researchers will compare different hospital units to see if changing communication affects the number of patients with delirium. The main questions it aims to answer are: • Does sharing information about communication and/or providing hearing devices change the number of hospital patients with delirium? Participants in the study will be asked to complete delirium screenings and answer questions about their hearing and communication.

NCT ID: NCT05897060 Recruiting - Clinical trials for Post-Operative Confusion

Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement

POC-SctO2
Start date: May 11, 2023
Phase: N/A
Study type: Interventional

The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven reproducible and standardized loss of brain autoregulation induced during transcatheter aortic valve replacement procedures. The main question it aims to answer is: assessing and improving the sensitivity/specificity of Braindex SctO2 measurements. Study type: single-center, prospective, interventional, open-label, exploratory clinical trial. Participant population/health status: - Patient, male or female, over 18 years of age - Patient scheduled for percutaneous femoral aortic valve replacement with aortic valve balloon deployment (Edwards Sapien valve) under simple sedation with Remifentanil (TIVA), with spontaneous ventilation. The expected outcome of this research is to optimize in vivo the algorithm for calculating the SctO2 of the BRAINDEX sensor in surgical conditions, in a context of proven low cerebral flow, on a target population. It is expected, in the long run, a better quality of detection of the loss of cerebral auto-regulation leading to a faster and optimal correction, thus potentially limiting the risk of POCD, subcortical stroke and postoperative cognitive decline.

NCT ID: NCT05803447 Completed - Suicidal Behaviour Clinical Trials

Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Psychiatric Patients

Start date: September 1, 2016
Phase:
Study type: Observational

The aim of this study was to analyse the level of cognitive functioning of patients with history of suicidal behaviour suffering from depression and schizophrenia, and to evaluate their oxidative stress parameters and selected biochemical parameters on the basis of bloodwork.

NCT ID: NCT05796830 Not yet recruiting - Quality of Life Clinical Trials

Determination of the Effect of Puzzle Use in Elderly Patients

Start date: March 28, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and face-to-face interview techniques.

NCT ID: NCT05785689 Not yet recruiting - Clinical trials for Postoperative Complications

Autonomous Nervous System Regulated Paediatric Anaesthesia With Dexmedetomidine or Placebo

ANNA
Start date: April 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this randomized, double blinded study is to examine in children whether postoperative agitation can be reduced. The main question it aims to answer is Will optimized, monitor guided analgesic treatment and dexmedetomidine reduce postoperative agitation Participants will receive a standard anaesthesia regimen and on top of that, a titrable remifentanil infusion guided via Mdoloris Anastasia nociception index (ANI) monitor will be added. Additionally, the patients will receive either bolus placebo or bolus dexmedetomidine. The postoperative agitation measured via the Richmond agitation and sedation scale (RASS) score, will be compared. Secondary outcome measures including carbon dioxide trends will be made.

NCT ID: NCT05510401 Recruiting - Clinical trials for Cognitive Impairment

Evaluation of Safe Use of SECURIDRAP® SELFIA®

SECURIDRAP
Start date: May 18, 2022
Phase: N/A
Study type: Interventional

Interventional, multicenter, prospective and non-comparative clinical investigation carried out in 9 French establishments in order to assess the safety of the SÉCURIDRAP® SELFIA® bedding by mesasuring all the adverse events likend to its use. Following the withdrawal from the market of the first version of the SECURIDRAP® SELFIA®, this clinical investigation is being carried out at the request and on the recommandation of the ASNM in order to assess the safety of the second version of the SECURIDRAP® SELFIA® coating.

NCT ID: NCT05398211 Completed - Delirium in Old Age Clinical Trials

Music Therapy as a Treatment for Delirium in Acutely Hospitalized Older Patients

Start date: June 15, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess feasibility and potential effectiveness of two different music interventions for managing delirium symptoms in acute geriatric patients.

NCT ID: NCT05378659 Recruiting - Alzheimer Disease Clinical Trials

Neuroinflammation and Alzheimer's Pathology in POCD

POCD
Start date: November 1, 2021
Phase:
Study type: Observational

The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD). To achieve this goal, the investigators will combine blood and cerebrospinal fluid (CSF) sampling, standardized cognitive tests, and dynamic neurophysiological markers of cortical network dysfunction in the form of event-related potentials (ERPs), to assess the link between neurodegeneration and neuroinflammation in the pathogenesis of POCD.