Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease — ENGAGE-PD  

Parkinson Disease Clinical Trial

Official title: ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease

Status Recruiting

Clinical Trial Summary

The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).

Clinical Trial Description

Postural instability, gait impairment, and falls are among the greatest unmet needs in Parkinson disease (PD). A single fall can be catastrophic, and impairments that limit mobility lead to social isolation or depression, and adversely affect bone and cardiovascular health. Unfortunately, postural instability and gait disorders are refractory to current pharmacological and surgical treatments, including deep brain stimulation (DBS). This project will directly address this pressing need. We will recruit participants to perform a gait task, using a new, alternating DBS frequency paradigm, while body movements and neural signals are recorded. The findings will lead to improved therapies to address these symptoms in the future. ;

Related Conditions & MeSH terms

• Accidental Fall
• Deep Brain Stimulation
• Disease Progression
• Gait Disorders, Neurologic
• Nervous System Diseases
• Parkinson Disease
• Subthalamic Nucleus

• NCT number: NCT05022147
• Study type: Interventional
• Source: The Cleveland Clinic
• Contact: James Liao, MD PhD
• Phone: 216-445-1108
• Email: liaoj2@ccf.org
• Status: Recruiting
• Phase: Phase 1
• Start date: October 4, 2021
• Completion date: July 2024