Diarrhea Clinical Trial
Official title:
Evaluating Low-cost Automatic Water Disinfection Systems to Improve Water Quality and Child Health in Urban Bangladesh
Verified date | May 2017 |
Source | Stanford University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Municipal water networks within industrialized countries typically rely on centralized treatment to manage piped water quality. Optimal water quality at the tap, however, requires well-maintained piped distribution networks, and performs best when piped systems are fully pressurized. In low-income cities such as Dhaka, water distribution networks are inadequately maintained and typically supply intermittent service; as such, they are vulnerable to recontamination during negative pressure events. Among populations accessing these types of improved water sources in urban settings (e.g. shared taps), it is unknown if consistent treatment to provide chlorinated water at the point of collection would have a significant health benefit. Furthermore, almost all previous studies of water treatment interventions in low-income countries have been unblinded with self-reported diarrhea as the main outcome, casting doubt that reported impacts of water disinfection on diarrhea are not due entirely to social desirability bias. Stanford University in collaboration with icddr,b will conduct a randomized evaluation to assess the impact on access to automatically chlorinated water on water quality and child health.
Status | Completed |
Enrollment | 1549 |
Est. completion date | December 20, 2016 |
Est. primary completion date | December 20, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A to 60 Months |
Eligibility |
Inclusion Criteria: - Households with at least one child under 60 months old - Households using enrolled shared water point as primary drinking water source Exclusion Criteria: - Households with a private drinking water source Note: New births and children under 60 months that migrate into compounds accessing the enrolled water points for drinking water will be enrolled into the study. |
Country | Name | City | State |
---|---|---|---|
Bangladesh | Tongi and Dhaka Uddan | Tongi/Dhaka | Gazipur |
Lead Sponsor | Collaborator |
---|---|
Stanford University | International Centre for Diarrhoeal Disease Research, Bangladesh |
Bangladesh,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Microbial water quality | Colony forming units of the fecal indicator bacteria, E. coli | Measured monthly among a subset of households, for 16 months post baseline | |
Other | Chlorine residual in household stored drinking water | Free chlorine residual in ppm | Measured every 2-3 months for 16 months post baseline | |
Other | health related treatment and associated cost | Measured every 2-3 months for 16 months post baseline | ||
Primary | Diarrhea longitudinal prevalence | 1-week recall period, case definition is 3 or more loose/watery bowel movements in 24 hours | Measured every 2-3 months for 16 months post baseline | |
Secondary | Weight-for-age-z-score | Weight-for-age z-score among children under five years | Measured every 2-3 months for 16 months post baseline | |
Secondary | Height-for-age-z-score | Height-for-age z-score among children under five | Measured at baseline and 16 months after baseline | |
Secondary | Respiratory illness longitudinal prevalence | one week recall period, symptoms include congestion, cough, difficulty breathing | Measured every 2-3 months for 16 months post baseline | |
Secondary | C-reactive protein | Measured at baseline and conclusion of study (16 months post baseline) among children under five | ||
Secondary | total immunoglobin G (IgG) | Measured at baseline and conclusion of study (16 months post baseline) among children under five | ||
Secondary | Prevalence and number of enteric pathogens | Measured 6-12 months after intervention delivery among children under five | ||
Secondary | Caregiver defined diarrhea | 1-week recall period, defined with local Bengali word for diarrhea | Measured every 2-3 months for 16 months post baseline |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT06283784 -
Study To Evaluate The Efficacy of a Proprietary Mix of Live Probiotics In The Prophylaxis Of Diarrhea In Adult Patients
|
N/A | |
Recruiting |
NCT03851835 -
Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis
|
Phase 3 | |
Completed |
NCT04003181 -
The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon
|
N/A | |
Completed |
NCT03596827 -
The Protective Immune Response to Attenuated Enterotoxigenic Escherichia Coli Infection
|
N/A | |
Recruiting |
NCT05372068 -
Cement flooRs AnD chiLd hEalth (CRADLE)
|
N/A | |
Completed |
NCT03972618 -
Evaluation of the Efficacy of Sawyer Point One Filters in Schools and Homes in the Dominican Republic
|
N/A | |
Completed |
NCT05207618 -
Utility of the Administration of Chesnut and Quebracho Extract for Irritable Bowel Syndrome Diarrhea Predominant
|
N/A | |
Not yet recruiting |
NCT05052489 -
Registry and Clinical Observation of Children With Diarrhoeal Disease
|
||
Completed |
NCT02428647 -
Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation
|
N/A | |
Completed |
NCT02541695 -
Characterization of Resistance Against Live-attenuated Diarrhoeagenic E. Coli
|
N/A | |
Completed |
NCT02197780 -
Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD
|
N/A | |
Completed |
NCT01968408 -
Lactobacillus Reuteri DSM 17938 in Preventing Nosocomial Diarrhea in Children
|
Phase 3 | |
Completed |
NCT01739231 -
Live Attenuated ETEC Vaccine ACE527 With and Without dmLT Adjuvant in Adults
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT01382199 -
Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients
|
Phase 3 | |
Terminated |
NCT01472211 -
Water-based Zinc Intervention Trial in Zinc Deficient Children
|
Phase 0 | |
Completed |
NCT01438645 -
ScopeGuide-assisted Colonoscopy Versus Conventional Colonoscopy
|
N/A | |
Terminated |
NCT01048567 -
Efficacy and Safety of Lactobacillus Acidophilus/Rhamnosus Combination for the Prevention of Antibiotic-associated Diarrhea in the Elderly
|
Phase 2 | |
Completed |
NCT01371656 -
Levofloxacin in Preventing Infection in Young Patients With Acute Leukemia Receiving Chemotherapy or Undergoing Stem Cell Transplantation
|
Phase 3 | |
Completed |
NCT00914225 -
Effect of Bednets and a Water Purification Device on HIV Disease Progression Among ART naïve Patients in Kenya
|
N/A | |
Completed |
NCT00760851 -
Yogurt Study in Children 2-4 Years Old Attending Daycare
|
Phase 3 |