Exercise and Time of Day in Type 2 Diabetes

Diabetes Mellitus, Type 2 Clinical Trial

Official title:

Exercise Time of Day for Cardiometabolic Health in Type 2 Diabetes

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05108987
• Other study ID #: Pro2021001183
• Status: Recruiting
• Phase: N/A
• Start date: September 25, 2021
• Est. completion date: September 25, 2025

Study information

• Verified date: May 2023
• Source: Rutgers, The State University of New Jersey
• Contact: Steven K Malin
• Phone: 848-932-7054
• Email: steven.malin[@]rutgers.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall purpose of the study is to test the effect of Noom on exercise and diet advice in adults with type 2 diabetes. The overarching hypothesis is that the use of Noom may promote better dietary adherence during an exercise program, thereby promoting greater weight loss and cardiometabolic health compared to lifestyle advice only. In particular, the investigators anticipate that changes in metabolic and vascular insulin sensitivity will correlate with glycemic control and blood pressure changes.

Description:

Type 2 diabetes (T2D) is associated with a 3-fold cardiovascular disease (CVD) mortality risk compared with healthy controls, and it is estimated that 30 million adults in the United States have the disease. In recent years the American Diabetes Association (ADA) and American College of Sports Medicine (ACSM) recommend moderate intensity (40-60% heart rate max, HRmax) aerobic exercise 3-5d/wk for the management of T2D. The statement also recognized that higher exercise intensity (>60% HRmax) predicts better blood glucose control than exercise volume. Cardiovascular health (e.g. fitness, blood pressure, etc.) also appears to respond in an exercise dose dependent manner. Despite these suggestions, many people exercising compensate by eating calories back from exercise, thereby negating weight loss. Moreover, compliance and adherence to exercise and diet medical counsel is disappointingly low.

Recent work has begun to target the best time of day to exercise in effort to improve weight loss and related health. This has evolved in part since circadian biology reveals people tend to become glucose intolerant, and develop insulin resistance and endothelial dysfunction in the evening compared with morning. As a result, it would be reasonable to hypothesize that exercise in the afternoon may be best at combating natural declines in health as well as optimizing training adaptations. However, not all studies agree that afternoon is the best time to exercise. In fact, some have demonstrated that 12 wks of aerobic plus resistance exercise improved glycemic control whether performed in the morning or afternoon in adults with T2D. Moreover, consistent morning exercise has been suggested to improve exercise adherence through possible enjoyment as well as lead to greater weight loss. Taken together, additional work is warranted to understand time of day in which exercise is performed given circadian influence may contribute to variations in favorable metabolic as well as vascular adaptation for CVD prevention/treatment. Excitingly, we have preliminary data showing that afternoon exercise induces greater weight loss, reductions in food intake as well as perceptions of appetite and increased insulin sensitivity when compared to morning exercisers. Thus, the overall purpose of this proposal is to determine whether exercise time of day differentially enhances likelihood of weight loss via appetite regulation as well as glycemic control. Our overarching hypothesis is that afternoon exercise will enhance the effectiveness of exercise to induce weight loss, improve appetite and improve glycemic regulation compared to exercise in the morning. Taken together, findings from this study will inform public health recommendations to contemporary behavioral strategies to treat T2D. The study will also provide much needed experimental evidence to time of day in which exercise is performed influences public health risk.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 63
• Est. completion date: September 25, 2025
• Est. primary completion date: September 25, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years to 70 Years

Eligibility

Inclusion Criteria:

• Male or female >30 and <70 years old.

• Has a body mass index >28 and <45 kg/m2.

• Previously diagnosed with T2DM.

• Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).

Exclusion Criteria:

• Morbidly obese patients (BMI >46 kg/m2) and overweight/lean patients (BMI <27 kg/m2)

• Evidence of type 1 diabetes and diabetics requiring insulin therapy

• Subjects who have not been weight stable (>2 kg weight change in past 3 months)

• Subjects who have been recently active (>30 min of moderate/high intensity exercise, 2 times/week).

• Subjects who are smokers or who have quit smoking <1 years ago

• Subjects with abnormal estimated glomerular filtration rate (eGFR).

• Hypertriglyceridemic (>400 mg/dl) and hypercholesterolemic (>260 mg/dl) subjects

• Hypertensive (>160/100 mmHg)

• Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.

• Pregnant (as evidenced by positive urine pregnancy test) or nursing women

• Subjects with contraindications to participation in an exercise training program

• Currently taking active weight suppression medication (e.g. phentermine,orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzephetamine, diethylpropion, phendimetrazine)

• Known hypersensitivity to perflutren (contained in Definity)

Related Conditions & MeSH terms

• Diabetes Mellitus
• Diabetes Mellitus, Type 2
• Metabolic Syndrome

Intervention

Behavioral:
• Exercise Morning
Exercise at moderate to hard intensity will be performed in the morning for up to 10 sessions for about 1 hour under supervision in the morning.
• Exercise Afternoon
Exercise at moderate to hard intensity will be performed in the morning for up to 10 sessions for about 1 hour under supervision in the afternoon.

Locations

Country	Name	City	State
United States	New Jersey Institute for Food, Nutrition, and Health	New Brunswick	New Jersey
United States	Robert Wood Johnson University Hospital Clinical Research Center	New Brunswick	New Jersey
United States	Rutgers University Loree Gymnasium	New Brunswick	New Jersey

Sponsors (2)

Lead Sponsor	Collaborator
Rutgers, The State University of New Jersey	Noom Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Body Weight	The primary outcome is changes in body weight pre- and post-intervention	Over the course of 2 weeks.
Secondary	Glucose Tolerance	We will examine the influence of Noom on the glucose area under the curve during the oral glucose tolerance test.	Over the course of 2 weeks.
Secondary	Flow-mediated dilation	We will assess blood flow to better understand nutrient/glucose delivery.	Over the course of 2 weeks.