Clinical Trials Logo

Clinical Trial Summary

This is a prospective, randomized double blind placebo controlled parallel group trial to assess the effect of Effervescent calcium magnesium citrate (EffCaMgCitrate) and dapagliflozin on surrogate markers of kidney and cardiovascular health in patients with stage 3b-4 Chronic Kidney Disease (CKD). Randomization: 1. Placebo EffCaMgCitrate + Placebo Dapagliflozin BID (bis in die / two times) 2. EffCaMgCitrate 480mg Mg (total dosage per day) + Placebo Dapagliflozin BID 3. Dapagliflozin 10mg (total dosage per day) + Placebo EffCaMgCitrate BID This study includes three clinic in person visits and weekly telephone visits for 24 weeks. 1. Recruit 30 patients with CKD stages 3b-4 and randomize them in double-blind fashion to either placebo, CaMgcitrate 480mg Mg or dapagliflozin 10mg twice daily for 24 weeks 2. Determine the effect of interventions on the primary outcome variable serum klotho measured by immunoprecipitation-immunoblot 3. Determine the effect of interventions on magnesium.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05033054
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Robert Toto, MD
Phone 214-645-8267
Email [email protected]
Status Not yet recruiting
Phase Phase 1
Start date September 2021
Completion date August 2022

See also
  Status Clinical Trial Phase
Recruiting NCT03975309 - DHS MIND Metabolomics
Completed NCT01855399 - Technologically Enhanced Coaching: A Program to Improve Diabetes Outcomes N/A
Completed NCT01819129 - Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 Diabetes Phase 3
Completed NCT01437592 - Investigating the Pharmacokinetic Properties of NN1250 in Healthy Chinese Subjects Phase 1
Completed NCT01696266 - An International Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes
Active, not recruiting NCT04082585 - Total Health Improvement Program Research Project
Completed NCT03390179 - Hyperglycemic Response and Steroid Administration After Surgery (DexGlySurgery)
Not yet recruiting NCT05029804 - Effect of Walking Exercise Training on Adherence to Disease Management and Metabolic Control in Diabetes N/A
Recruiting NCT04427982 - Dance and Diabetes/Prediabetes Self-Management N/A
Active, not recruiting NCT02356848 - STEP UP to Avert Amputation in Diabetes N/A
Completed NCT03292185 - A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide Compared With Insulin Degludec and Liraglutide in Healthy Chinese Subjects Phase 1
Recruiting NCT04496401 - PK Study in Diabetic Transplant récipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus Phase 4
Recruiting NCT04938557 - Automated Insulin Delivery Amongst Pregnant Women With Type 1 Diabetes N/A
Completed NCT01809288 - Identifying Risk for Diabetes and Heart Disease in Women
Completed NCT03675360 - Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial N/A
Completed NCT03362528 - Database and Calibration of a Non-invasive Glucose Monitoring Device N/A
Completed NCT02249871 - Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects Phase 1
Terminated NCT02416193 - Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes? (THINK-D) Phase 2
Completed NCT01850615 - Efficacy and Safety of FIAsp in a Basal-bolus Regimen Versus Basal Insulin Therapy, Both in Combination With Metformin in Adult Subjects With Type 2 Diabetes Phase 3
Recruiting NCT05007990 - Caregiving Networks Across Disease Context and the Life Course