Biomarkers During Pregnancy

Status Active, not recruiting

Clinical Trial Summary

Clinical Trial Description

This study aims to obtain preliminary data for utility of alternate biomarkers for monitoring glucose control in diabetic women during pregnancy and/or predicting risk of adverse neonatal events in these women. Our population is unique compared to published studies and contains significant numbers of African American women and overweight or obese women. Two of these markers have been examined in several other populations of pregnant women and have shown utility for both outcomes. However, the recommended levels of these markers need to be determined in specific populations as ethnicity and BMI affect the values. Values obtained in recruited women will be compared with biobank samples from women who have no evidence or history of diabetes. Additionally, two other potentially promising markers will be examined (beta-hydroxybutyrate and triglycerides). Both these analytes change during pregnancy and beta-hydroxybutyrate has shown correlation with large for gestational status or macrosomia in some studies. A combination of markers may be a better predictor of adverse neonatal outcomes than a single marker. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04108455
Study type	Observational
Source	Washington University School of Medicine
Contact
Status	Active, not recruiting
Phase
Start date	March 15, 2019
Completion date	November 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05081037` - Integrated Hyperglycaemia Incentivised Postnatal Surveillance Study (I-HIPS)	N/A
Active, not recruiting	`NCT03249896` - Web/Smartphone-based Lifestyle Coaching Program in Pregnant Women With Gestational Diabetes	N/A
Terminated	`NCT03749889` - Low Carb vs Normal Carb in Pregnancy	N/A
Completed	`NCT03859193` - Education Nutritional Video for Gestational Diabetics	N/A
Recruiting	`NCT05037526` - Utility of Real Time Continuous Glucose Monitoring in the Care of Gestational Diabetes Versus Standard Care in Pregnancy Outcomes	N/A
Completed	`NCT06178250` - Placenta, Fetal Liver, Sectional Ductus Venosus Volumes Examined by Three-dimensional Ultrasound in the Second Trimester	N/A
Not yet recruiting	`NCT06445530` - Nutrition Optimization and Community Upliftment for Postpartum Recovery	N/A
Not yet recruiting	`NCT06310356` - Continuous Glucose Monitoring for Women With Gestational Diabetes	N/A
Recruiting	`NCT02590016` - Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial	Phase 4
Withdrawn	`NCT01947699` - Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide	Phase 4
Not yet recruiting	`NCT00883259` - Metformin and Gestational Diabetes in High-risk Patients: a RCTs	Phase 4
Recruiting	`NCT03008824` - Micronutrients in Pregnancy as a Risk Factor for Diabetes and Effects on Mother and Baby	N/A
Active, not recruiting	`NCT01340924` - Relationship Between Gestational Diabetes and Type 2 Diabetes
Completed	`NCT00534105` - Lipid Metabolism in Gestational Diabetes	N/A
Recruiting	`NCT00371306` - Comparison of Glucovance to Insulin for Diabetes During Pregnancy	N/A
Completed	`NCT03388723` - Intergenerational Programming of Diabesity in Offspring of Women With Gestational Diabetes Mellitus
Recruiting	`NCT04521712` - Postpartum Glycemia in Women at Risk For Persistent Hyperglycemia	N/A
Enrolling by invitation	`NCT03307486` - Gestational Diabetes: a Cohort Study	N/A
Active, not recruiting	`NCT03301792` - Group Versus Traditional Prenatal Care for Diabetes	N/A
Enrolling by invitation	`NCT05603793` - YoUng Adolescents' behaViour, musculoskeletAl heAlth, Growth & Nutrition