Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian Foods

Diabetes Clinical Trial

Official title:

Glycemic and Insulinemic Response of Pasta Products in Comparison to Asian

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03646812
• Other study ID #: 2018/00622
• Status: Completed
• Phase: N/A
• Start date: August 10, 2018
• Est. completion date: June 1, 2020

Study information

• Verified date: August 2023
• Source: Clinical Nutrition Research Centre, Singapore
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to determine the glycaemic and insulinaemic index of pasta products and local foods. It is hypothesized that different pasta cuts and wholegrain composition of pasta and local foods have different GI depending on the nature of the carbohydrate content and the food structure within each food.

Description:

There will be a total of 9 test sessions and each session will last up to 3.5 hours. The order of sessions will be determined with an online randomizer. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations Subject will be served the test food and to consume within15 minutes Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: June 1, 2020
• Est. primary completion date: June 1, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 21 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy Asian - Indian and Chinese ethnicity

• Age between 21-40 years

• Body mass index between 18.5 to 25 kg/m2

• Normal blood pressure (<140/90 mmHg)

• Fasting blood glucose < 6 mmol/L

Exclusion Criteria:

• Is a current smoker

• Is currently pregnant

• Have any metabolic diseases (such as diabetes, hypertension etc)

• Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)

• Have medical conditions and/or taking medications known to affect glycemia(glucocorticoids, thyroid hormones, thiazide diuretics)

• Have any major organ dysfunction (e.g. cardiovascular, respiratory, hepatic, renal, gastrointestinal) that may influence taste, olfaction, appetite, digestion, metabolism, absorption or elimination of test foods, nutraceutical or drug

• Have any severe food allergy (e.g. anaphylaxis to peanuts)

• Have any known allergies to any food components of the study protocol

• Have active Tuberculosis (TB) or currently receiving treatment for TB

• Have any known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)

• Is a study team member or an immediate family of any study team member. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.

• enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study.

• Have partake in sports at the competitive and/or endurance levels

• Have intentionally restrict food intake

Related Conditions & MeSH terms

• Diabetes

Intervention

Other:
• Glucose Reference 1
Glucose contains 50g of available carbohydrates
• Glucose Reference 2
Glucose contains 50g of available carbohydrates
• Glucose Reference 3
Glucose contains 50g of available carbohydrates
• Semolina Penne
Semolina Penne contains 50g of available carbohydrates
• Wholegrain Penne
Wholegrain Penne contains 50g of available carbohydrates
• Semolina Spaghetti
Semolina Spaghetti contains 50g of available carbohydrates
• Wholegrain Spaghetti
Wholegrain Spaghetti contains 50g of available carbohydrates
• Jasmine Rice
Jasmine Rice contains 50g of available carbohydrates
• Asian Noodles
Asian Noodles contains 50g of available carbohydrates

Locations

Country	Name	City	State
Singapore	Clinical Nutrition Research Centre	Singapore

Sponsors (2)

Lead Sponsor	Collaborator
Clinical Nutrition Research Centre, Singapore	Barilla Singapore Pte Ltd

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucose	Blood will be collected and measured using hemocue analyzer.	up to 180 minutes
Primary	Insulin	Blood will be collected and measured using COBAS analyzer.	up to 180 minutes