Diabetes Mellitus Clinical Trial
Official title:
Dried Fruit as a Means for Lowering the Glycemic Response to High Glycemic Index-carbohydrate Foods
Dried fruits show promising potential for the management of blood glucose. Previous trials have reported beneficial effects of raisins on post-prandial glucose and insulin responses in healthy individuals when compared with white bread. However, to date there is limited data evaluating the potential beneficial effects of other dried fruits (i.e. sultanas, dates and apricots). It is also unclear whether dried fruits can be used to lower the postprandial glycemic responses to high-GI carbohydrate foods by either displacing available carbohydrate (displacement effect) or providing 'catalytic' doses of fructose ('catalytic' fructose effect). To address these questions, the investigators propose to assess the GI of 4 common types of dried fruit (raisins, sultanas, dates, apricots) (GI effect) and their ability to decrease the postprandial glycemic response to white bread by either partially displacing available carbohydrate (displacement effect) or by providing a 'catalytic' dose of fructose ('catalytic' fructose effect).
Status | Not yet recruiting |
Enrollment | 10 |
Est. completion date | |
Est. primary completion date | December 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Adult males and/or non-pregnant females aged 18-75 years and in good health Exclusion Criteria: - Age less than 18 years or greater than 75 years - BMI<18.5kg/m2 or >30kg/m2 - Known history of HIV, liver disease, kidney disease, thyroid disease, diabetes, heart disease or or any other major illnesses that may affect carbohydrate metabolism - Subjects using medications which might, either: 1) make participation dangerous to the subject or to others, or 2) affect the results - Subjects who cannot or will not comply with the experimental procedures or do not follow the clinic's safety guidelines. |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator)
Country | Name | City | State |
---|---|---|---|
Canada | GI Labs | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
University of Toronto | Glycemia Consulting Inc., International Nut and Dried Fruit Council (INC), The National Dried Fruit Trade Association (NDFTA) |
Canada,
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* Note: There are 18 references in all — Click here to view all references
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Primary | Glycemic index (GI) | Up to 120min | No |
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