Diabetes Clinical Trial
Official title:
Immediate and Long-term Induction of Incretin Release by Artificial Sweeteners 2
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft
drinks may play a role in the development of diabetes.
Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence
metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and
even modulate incretin release.
Data on human subjects are sparse and controversial, especially in a long-term manner. We
therefore conduct a cross-over study to assess metabolic response to sweetened vs.
non-sweetened soft drinks, which are consumed over a period of 4 weeks.
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft
drinks may play a role in the development of diabetes.
Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence
metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and
even modulate incretin release.
Data on human subjects are sparse and controversial, especially in a long-term manner. We
therefore conduct a cross-over study to assess metabolic response to sweetened vs.
non-sweetened soft drinks, which are consumed over a period of 4 weeks. Metabolic assessment
will be based on oral glucose tolerance tests.
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