Diabetes Clinical Trial
Official title:
Immediate and Long-term Induction of Incretin Release by Artificial Sweeteners 1
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft
drinks may play a role in the development of diabetes.
Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence
metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and
even modulate incretin release.
However, it is unclear, if these findings are valid for all kinds of AS, as they are
chemically different. Furthermore, data on human subjects are sparse and controversial.
The investigators will therefore conduct 7 consecutive single oral stimulations with glucose
or AS alone or a combination. Three different AS will be tested.
Epidemiological data suggest, that not only sugar-based, but also artificially sweetened soft
drinks may play a role in the development of diabetes.
Recent studies in animals and humans have shown, that artificial sweeteners (AS) influence
metabolic responses after glucose ingestion, possibly alter the intestinal microbiome and
even modulate incretin release.
However, it is unclear, if these findings are valid for all kinds of AS, as they are
chemically different. Up to now, no single study has ever compared metabolic responses to
different AS in the same subjects. Furthermore, data on human subjects are sparse and
controversial. This is partially explained by different methodical approaches such as
intragastral/intraduodenal application of AS, rather than conventional oral consumption.
The investigators will therefore conduct 7 consecutive single oral stimulations with glucose
or AS alone or a combination. Three different AS will be tested: saccharin, aspartame and
sucralose.
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