Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People

Diabetes Mellitus Clinical Trial

— Lixi  

Official title:

Effects of Lixisenatide on Gastric Emptying, Glycaemia and 'Postprandial' Blood Pressure in Type 2 Diabetes and Healthy Subjects.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02308254
• Other study ID #: 130419
• Status: Recruiting
• Phase: Phase 1/Phase 2
• First received: November 3, 2014
• Last updated: October 27, 2015
• Start date: November 2013
• Est. completion date: April 2016

Study information

• Verified date: October 2015
• Source: Royal Adelaide Hospital
• Contact: Rachael S Tippett, BSc Honours
• Phone: 8222 2915
• Email: rachael.tippett[@]adelaide.edu.au
• Is FDA regulated: No
• Health authority: Australia: Department of Health and Ageing Therapeutic Goods Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effects of the drug lixisenatide on blood sugar levels, stomach emptying, blood pressure and heart rate, release of gut hormones and blood flow in the gut after a glucose drink in both healthy subjects and people with type 2 diabetes. If lixisenatide is shown to be effective, it would encourage ongoing evaluation of its potential use in the management of the falls in blood pressure following a meal in diabetic patients.

Description:

Lixisenatide is a drug that has been shown to reduce postprandial glycaemia in people with type 2 diabetes and is now approved for use in Australia. Although slowing of gastric emptying is likely to be the dominant mechanism by which lixisenatide reduces postprandial glycaemia after a meal, the effects of lixisenatide on gastric emptying have hitherto not been quantified by the 'gold standard' technique of scintigraphy. The study would determine and evaluate for the first time the magnitude of, and the relationship between lixisenatide on glycaemia with those on gastric emptying with scintigraphy. This information will be of fundamental significance to the effective use of lixisenatide in the management of people with type 2 diabetes that suffer from postprandial hypotension.

Postprandial hypotension represents an important clinical disorder that occurs frequently in the elderly and people with type 2 diabetes and for which current management is suboptimal. While the mechanisms mediating postprandial hypotension are poorly understood, impaired regulation of splanchnic blood flow, gastric distension, the rate of small intestinal delivery and neural and hormonal mechanisms have been identified as possible pathophysiological mechanisms. Meal ingestion is associated with splanchnic blood pooling and a consequent reduction in venous return of blood to the heart. In healthy young and older individuals, with intact baroreflex mechanisms, these changes induce a rise in heart rate, stoke volume and cardiac output leading to a compensatory rise in blood pressure. However, patients with postprandial hypotension, these responses are inadequate to maintain blood pressure. The magnitude of the fall in blood pressure is greater when gastric emptying is more rapid and that slowing gastric emptying can markedly attenuate the postprandial fall in blood pressure in both healthy older subjects and type 2 patients.

There is currently no information about the effect of lixisenatide on postprandial blood pressure and splanchnic blood flow in patients with type 2 diabetes.

The purpose of this study would determine whether lixisenatide reduces the postprandial fall in blood pressure and related effects of gastric emptying to those on blood pressure, heart rate and splanchnic blood flow.

The use of lixisenatide on appetite and energy intake and how these relate to effects of gastric emptying is lacking.

It is hypothesized that lixisenatide will slow gastric emptying of oral glucose; attenuate both fasting and the postprandial rise in blood glucose; attenuate the magnitude of the fall in blood pressure, rise in heart rate and increase in SMA flow and reduce hunger, increase fullness and decrease energy intake at a buffet meal with greater effects in patients with type 2 diabetes that healthy subjects.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: April 2016
• Est. primary completion date: April 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 40 Years to 80 Years

Eligibility

Inclusion Criteria:

• Healthy subjects:

• Male or female (females using appropriate contraceptive method or willing to undergo pregnancy test)

• Body Mass Index (BMI) 19 - 30 kg/m2

• Type 2 Diabetic Patients:

• As per "healthy subjects"

• Type 2 diabetes (World Health Organisation (WHO) criteria) managed by diet alone or on metformin

• Glycated haemoglobin >6.0% and <8.5%

Exclusion Criteria:

• Subjects with a history of severe respiratory, cardiovascular, hepatic and/or renal disease (severe in that the social or physical manifestations of the disease, or living with the condition, impact negatively and significantly on the individuals' ability to lead a normal day to day life), chronic alcohol abuse or epilepsy (excluded by history) or if iron status, or liver function tests are outside the following ranges:

1. Alanine aminotransferase (ALT) 0 - 55 U/L

2. Alkaline phosphatase 30 - 110 U/L

3. Aspartate transaminase 0 - 45 U/L

4. Amylase and/or lipase >3 x ULN

5. Bilirubin 6 - 24 mmol/L

6. Ferritin 15 - 200 ng/mL (females); 30 - 300 ng/mL (males)

7. Haemoglobin 115 - 155 g/L (females); 135 - 172 g/L (males)

• Subjects with a creatinine clearance cut-off of <50 ml/min

• Subjects requiring medication likely to influence blood pressure or gastrointestinal function

• Subjects with a past history of gastrointestinal disease, including known gastroparesis, significant upper gastrointestinal symptoms and previous gastric surgery

• Subjects with a past history of unexplained pancreatitis, chronic pancreatitis, pancreatectomy

• Subjects with a current or prior history of c-cell carcinoma

• Smoking > 10 cigarettes/day

• Alchohol consumption > 20 g/day

• Subjects who have donated blood in the previous 12 weeks

• Women of childbearing potential with no effective contraceptive method (defined as premenopausal, not surgically sterile women for at least 3 months prior to the time of screening) must have a confirmed negative urine B-hCG pregnancy test at screening visit. They must also use an effective contraceptive method throughout the study, and agree to repeat urine pregnancy test at designated visits.

• Lactation

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Diabetes Mellitus
• Gastroparesis

Intervention

Drug:
• Lixisenatide
Abdominal administration
• Placebo
Abdominal administration

Locations

Country	Name	City	State
Australia	Discipline of Medicine, Royal Adelaide Hospital	Adelaide	South Australia

Sponsors (3)

Lead Sponsor	Collaborator
Royal Adelaide Hospital	National Health and Medical Research Council, Australia, Sanofi

Country where clinical trial is conducted

Australia, 

References & Publications (37)

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* Note: There are 37 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Intragastric distribution	percent retention in the proximal and distal stomach	3 hours per study	No
Other	Gastrointestinal hormone release (concentrations of GLP-1, GIP, C-peptide and 3-OMG)	concentrations of GLP-1, GIP, C-peptide and 3-OMG	4.5 hours per study	No
Other	Superior mesenteric artery blood flow	Doppler ultrasound (ml/min)	3.5 hours per study	No
Other	Appetite (visual analogue questionnaire)	sensations of hunger, fullness, desire to eat (mm)	4.5 hours per study	No
Other	Cardiac output	Finapres (L)	3.5 hours per study	No
Other	Stroke volume	Finapres (L)	3.5 hours per study	No
Primary	Blood Pressure	Systolic and diastolic blood pressure (mmHg)	4.5 hours per study	No
Secondary	Heart rate	Heart rate (beats per minute)	4.5 hours per study	No
Secondary	Gastric emptying rate	Gastric retention (percent in the total stomach)	3 hours per study	No
Secondary	Blood glucose concentration	Blood glucose (mmol/L)	3 hours per study	No