Clinical Trials Logo
  1. Home
  2. Diabetes Mellitus, Type 2
  3. NCT02127047

Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes — EXTYPE-1  

Diabetes Mellitus Type 1 Clinical Trial

Official title:
Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes

Clinical Trial Summary

Increasing evidence suggests pancreatic islet beta-cell regeneration occurs throughout the course of the disease in patients with type 1 diabetes. Therefore, decreased beta-cell mass in type 1 diabetes may be improved through inhibition of beta-cell destruction and stimulation of proliferation, even after prolonged duration of disease.

Physical activity improves insulin secretion via unknown underlying mechanisms. We recently observed that Interleukin-6 induces glucagon like Peptide (GLP)-1 production and release from the islet alpha-cell and the intestinal L-cell. Furthermore, exercise induces release of Interleukin-6 from skeletal muscle resulting in elevated circulating Interleukin-6 levels. Therefore we hypothesize that exercise-induced Interleukin-6 promotes glucagon like peptide-1 secretion from the islet α-cell and the intestinal L-cell, thereby providing a mechanism how physical activity can help maintain and improve beta-cell function in patients with type 1 diabetes. This mechanism can be enhanced by concomitant dipeptidyl peptidase-IV inhibition.

Physical activity is also known to enhance insulin sensitivity and to attenuate the immune system activity.

Therefore by combining physical activity and dipeptidyl peptidase-IV inhibition we aim to allow for beta-cell regeneration in a interventional randomized open-label study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02127047
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Phase 2
Start date November 2013
Completion date August 5, 2016
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT01508065 - Measuring and Monitoring Blood Glucose Levels Utilizing Non-invasive Blood Glucose Monitoring Device
Completed NCT01788033 - Effects of XOMA 052 on Insulin Production in Type 1 Diabetes Phase 2
Active, not recruiting NCT01271517 - Basal Analog Study - Comparison of Lantus or Levemir With NPH Insulin From T1DM Diagnosis Phase 4
Recruiting NCT01800734 - Mixed Meal Test in Type 1 Diabetes: Optimization of Artificial Pancreas-Pilot Study Phase 4
Recruiting NCT06088615 - Feasibility of Non-invasive Glucose Monitoring by Using Photothermal Deflectometry
Completed NCT01689090 - Diameter Changes of Retinal Vessels During Hypoxia N/A
Completed NCT00006505 - Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression Phase 2
Not yet recruiting NCT06217302 - Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease Phase 3
Recruiting NCT02750111 - Continuous Glucose Monitoring During Intecorse in Young Adults With Type 1 Diabetes N/A
Recruiting NCT02545062 - MoCa Test for the Early Detection of Mild Cognitive Impairment During Annual Assessment of Young Adults With Diabetes and in a Control Group Without Diabetes N/A
Completed NCT02146651 - A Double-blinded, Randomised, Four-period Crossover Euglycemic Clamp Trial Investigating the Dose-response and Dose-exposure Relationship of BioChaperone Insulin Lispro in Three Different Doses in Subjects With Type 1 Diabetes Phase 2
Completed NCT02538120 - Assessment of the Neurovascular Microcirculatory Response in Diabetes Type 1 Patients N/A
Completed NCT02403375 - Comparing Continuous Subcutaneous Insulin Infusion With Multiple Daily Injections to Reach HbA1c Targets in Children and Adolescents With Type 1 Diabetes N/A
Terminated NCT00896610 - Natural History of Autoimmune Diabetes and Its Complications
Terminated NCT02701257 - The iLet Introduction Study: A Feasibility Study of the iLet, a Fully Integrated Bihormonal Bionic Pancreas N/A
Completed NCT02094534 - A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics Phase 2
Completed NCT01334151 - Pharmacokinetic and Pharmacodynamic Properties of BIOD-105 and BIOD-107 Compared to Humalog® in Subjects With Type 1 Diabetes Phase 1
Active, not recruiting NCT02624804 - A Pilot Study of the Therapeutic Potential of Stem Cell Educator Therapy in Type 1 Diabetes Phase 1
Completed NCT02465411 - Long Term CGM Treatment in Patients With Type 1 Diabetes Treated With Insulin Injections N/A
Completed NCT02157155 - A Study of Intracellular Signaling in Muscle and Fat Cells During Ketosis N/A