Diabetes Clinical Trial
Official title:
Retrospective Cohort MRC ABPI STratification and Extreme Response Mechanism in Diabetes:
This study will examine extreme responders to second- and third-line Type 2 Diabetes (T2D) therapy using a retrospective approach and patients with slow or fast diabetes progression.
PILOT Phase (March 2013 - Dec 2014) Patients will be recruited initially from 2 centres, plus
Exeter as a pre-PILOT centre. Patients with particularly good or poor response to second- and
third-line Type 2 diabetes treatments and patients progressing to insulin either particularly
quickly or particularly slowly will be recruited from primary, secondary, or community
settings. Fasting blood and urine samples will be collected, along with standard biomeasures
and information will be collected about medical history and prescribing history.
All study documentation and sample materials will be sent out to sites from the coordinating
centre. Sites will be expected to process and freeze samples and send them to the Central
Laboratory managed by the Chief Inspector's site where they will be analysed for genetic
factors, glycaemic markers and other markers related to drug response.
POST-PILOT Phase (Jan 2015- Oct 2017): Subject to feasibility, interim analysis and
continuation of funding from Medical Research Council (MRC), this project will continue for
another three years.
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