End Stage Renal Disease Clinical Trial
Aim: Patients with type 2 diabetes mellitus (T2DM) and hemodialysis due to diabetic
nephropathy exhibit a high risk for sudden cardiac death (SCD). Preliminary data suggest
that beta-blocker treatment may reduce arrhythmias and mortality in this high-risk
population. However, no results from large-scale clinical outcome trials with beta-blockers
exist in this patient group and a broad, scientifically unapproved use of beta-blocker
treatment may not be justified due to potential harmful side-effects such as AV-block or
hypotension. In addition, we are lacking identified ECG surrogate parameters for SCD in this
high-risk population and on the occurrence of arrhythmias in temporary relationship to
hemodialysis sessions.
Therefore, the present study will identify surrogate parameters of SCD in hemodialysis
patients with T2DM and in an interventional trial investigate the suppressive effect of
beta-blockers on these identified ECG markers.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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