Diabetes in Pregnancy Clinical Trial
Official title:
Haptoglobin and Diabetes Complications in Pregnancy
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome
. The risk for vascular complications including: Intra uterine growth restriction (20%),
hypertension (31%), preeclampsia (15%), eclampsia and placental abruption are significantly
greater than those in background populations. The risk of developing vascular complications
in diabetes pregnancies although is correlated with the severity and length of the disease
is not fully understood. Enhanced oxidation has been suggested to be the underlying
abnormality responsible for some of the complications of diabetes.
Haptoglobin (Hp) is an abundant plasma glycoprotein produced in the liver. The best
understood function of Hp is to bind free hemoglobin (Hb) released from red blood cells.
Extracorpuscular Hb is a potent Fenton reagent.capable of of inflicting oxidative tissue
damage. Hp binds to Hb and serves to inhibit the oxidative potential of Hb by preventing the
release of heme iron.
The haptoglobin (Hp) gene at chromosomal locus 16q22 is polymorphic, with two common alleles
denoted 1 and 2. the prevalence of Hp 1-1, Hp 1-2 and Hp 2-2 genotypes is approximately 16%,
48% and 36%, respectively. In the western world. A total of five independent longitudinal
studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold
increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to
determine whether HP genotype plays important role in development of vascular complications
in pregastational pregnancies. and whether Hp genotype 2-2 is a risk factor for developing
gestational diabetes (GDM)
n/a
Observational Model: Cohort, Time Perspective: Prospective
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