Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

Diabetes Mellitus Clinical Trial

Official title:

Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01422668
• Other study ID #: UAEU: GI Dates Study
• Status: Completed
• Phase: Phase 3
• First received: August 18, 2011
• Last updated: August 23, 2011
• Start date: March 2010
• Est. completion date: June 2010

Study information

• Verified date: August 2011
• Source: United Arab Emirates University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.

Description:

Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.

Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: June 2010
• Est. primary completion date: June 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c =8%) on diet with or without metformin

Exclusion Criteria:

• morbid obesity (BMI > 40 kg/m2)

• pre diabetes

• pregnancy

• presence of gastroenterological disorders

• alimentary tract surgery

• a history of gastroenteritis in the prior six months

• any alcohol intake

• smoking

• taking any medications (except metformin)

• poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases

Related Conditions & MeSH terms

• Diabetes Mellitus

Intervention

Other:
• Khalas dates
every subject recieved 50 grams reducing carbohydrates equivalent of khalas dates

Locations

Country	Name	City	State
United Arab Emirates	Faculty of Medicine and Health Sciences UAE University	Al Ain	AB

Sponsors (1)

Lead Sponsor	Collaborator
United Arab Emirates University

Country where clinical trial is conducted

United Arab Emirates, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glycemic Index of Khalas dates with and without coffee	Every subject recieved 50 grams reducing sugars of Khalas dates with and without coffee. Measuring glucose level over 2 hours in Healthy subjects and over 3 hours in diabetic subjects as per a standard protocol.	2 or 3 hours