Diabetes Clinical Trial
Official title:
Effects of Febuxostat on Adipokines and Kidney Disease in Diabetic Chronic Kidney Disease
Hyperuricemia is emerging as a risk factor for development of diabetes and metabolic
syndrome. Recently, it was shown in in-vitro cell culture experiments that hyperuricemia
induces redox-dependent signaling and oxidative stress in adipocytes. By targeting levels of
uric acid with febuxostat we hypothesize that the levels of oxidative stress in adipose
tissue (obtained by fat biopsy) will decrease.
Primary aims of the study is to determine whether febuxostat therapy in overweight or obese,
diabetic patients with stage 3 CKD and high serum uric acid levels
1. decreases adipose tissue concentrations of thiobarbituric acid reactive substance
(TBARS), a marker of oxidative stress
2. increases adipose tissue expression and concentrations of adiponectin and
3. decreases urinary concentrations of transforming growth factor (TGF)- B1.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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