Diabetes Clinical Trial
Official title:
Comparison Between Sitagliptin Add-on Therapy and Insulin Dose Increase Therapy for Uncontrolled Type 2 Diabetes on Insulin Therapy
It is well established that inhibition of dipeptidyl peptidase (DPP)-IV reduces glucose
levels and preserves pancreatic beta cell function in patients with type 2 diabetes. DPP-IV
inhibitors stimulate insulin secretion as well as insulin biosynthesis and inhibit glucagon
secretion from pancreas by increasing incretin (GLP-1) levels. Recent studies reported that
combination therapy with DPP-IV inhibitors and other oral antidiabetic medication have
additive or synergistic effects in lowering glycose level, preserving beta-cell mass and
function as well as enhancing insulin sensitivity. However, there have been few studies
about the glucose lowering effect of DPP-IV inhibitors in patients with type 2 diabetes on
insulin treatment.
The researchers hypothesized that DPP-IV inhibitor add-on therapy to insulin treatment may
have favorable effects on glucose control and endogenous insulin secretory function in type
2 diabetic patients. The researchers plan to compare between sitagliptin (DPP-IV inhibitor)
add-on therapy and insulin dose increase therapy in uncontrolled type 2 diabetes on insulin
treatment.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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