Glycemic Index and Polyphenol Bioavailability of Potatoes

Diabetes Clinical Trial

— GI  

Official title:

A Trial to Measure the Glycemic Index and Polyphenol Bioavailability of Four Different Varieties of Potato.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01053793
• Other study ID #: 09-11-004
• Secondary ID: GFRC 09-11-004
• Status: Completed
• Phase: N/A
• First received: January 20, 2010
• Last updated: January 14, 2011
• Start date: January 2010
• Est. completion date: March 2010

Study information

• Verified date: January 2011
• Source: Guelph Food Research Centre
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Canadian Institutes of Health Research
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the glycemic index of four varieties of potatoes and to determine the bioavailability of polyphenols contained in these potatoes.

Description:

Ten healthy persons will have a fasting blood sample drawn and asked to randomly consume a 50g glucose drink (2 occasions), or 50g carbohydrate equivalent of cooked purple, red, yellow and white potatoes. Further blood samples will be obtained at 15,30, 45, 60, 90, 120, 180, 240 mins. Bloods from the first 2 hours will be analyzed for glucose and insulin to determine the glycemic response. Hourly blood samples will be analyzed for polyphenol to determine the bioavailability of polyphenols from the different potato variety. Urine samples will be collected before ingestion of the food items and again at 4 hours, and will be used to determine polyphenol bioavailability.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 2010
• Est. primary completion date: February 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy, non-smoker on no medication

• normal glucose tolerance

• willing to have a catheter inserted in forearm

Exclusion Criteria:

• abnormal glucose tolerance

• abnormal BMI

• on medication for a chronic disorder

Study Design

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Diabetes
• Insulin Resistance

Intervention

Other:
• Glycemic response to different varieties of potatoes
the glycemic response top 50g available carbohydrates from 4 potato varieties will be compared to a 50g glucose standard

Locations

Country	Name	City	State
Canada	Nutrasource Diagnostic Inc	Guelph	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
Guelph Food Research Centre	Nutrasource Diagnostics Inc.

Country where clinical trial is conducted

Canada, 

References & Publications (4)

Ramdath DD, Isaacs RL, Teelucksingh S, Wolever TM. Glycaemic index of selected staples commonly eaten in the Caribbean and the effects of boiling v. crushing. Br J Nutr. 2004 Jun;91(6):971-7. — View Citation

Wolever TM, Brand-Miller JC, Abernethy J, Astrup A, Atkinson F, Axelsen M, Björck I, Brighenti F, Brown R, Brynes A, Casiraghi MC, Cazaubiel M, Dahlqvist L, Delport E, Denyer GS, Erba D, Frost G, Granfeldt Y, Hampton S, Hart VA, Hätönen KA, Henry CJ, Hertzler S, Hull S, Jerling J, Johnston KL, Lightowler H, Mann N, Morgan L, Panlasigui LN, Pelkman C, Perry T, Pfeiffer AF, Pieters M, Ramdath DD, Ramsingh RT, Robert SD, Robinson C, Sarkkinen E, Scazzina F, Sison DC, Sloth B, Staniforth J, Tapola N, Valsta LM, Verkooijen I, Weickert MO, Weseler AR, Wilkie P, Zhang J. Measuring the glycemic index of foods: interlaboratory study. Am J Clin Nutr. 2008 Jan;87(1):247S-257S. — View Citation

Wolever TM, Isaacs RL, Ramdath DD. Lower diet glycaemic index in African than South Asian men in Trinidad and Tobago. Int J Food Sci Nutr. 2002 Jul;53(4):297-303. — View Citation

Wolever TM, Vorster HH, Björck I, Brand-Miller J, Brighenti F, Mann JI, Ramdath DD, Granfeldt Y, Holt S, Perry TL, Venter C, Xiaomei Wu. Determination of the glycaemic index of foods: interlaboratory study. Eur J Clin Nutr. 2003 Mar;57(3):475-82. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glycemic response		2 hrs	No
Secondary	Bioavailability of polyphenols from potatoes		4 hours	No