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NCT00732602 Clinical Trial

The Effects of GIP and GLP-2 on the Secretion of Glucagon in Patients With Type 1 Diabetes

Diabetes Mellitus Clinical Trial

Official title:
The Effects of GIP and GLP-2 on the Secretion of Glucagon in Patients With Type 1 Diabetes

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00732602
Other study ID # H-D-2007-0058
Secondary ID
Status Completed
Phase N/A
First received August 11, 2008
Last updated February 12, 2009
Start date January 2008

Study information
Verified date February 2009
Source University Hospital, Gentofte, Copenhagen
Contact n/a
Is FDA regulated No
Health authority Denmark: Ethics Committee
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine whether Glucose-dependent Insulinotropic Polypeptide (GIP) or Glucagon Like Peptide 2 (GLP-2) has an affect on the secretion of Glucagon from the pancreas in patients with type 1 diabetes mellitus.

Recruitment information / eligibility
Status Completed
Enrollment 8
Est. completion date
Est. primary completion date August 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Caucasians over 18 years with type 1 diabetes (WHO criteria)

- Arginine test without rise in plasma C-peptide

- Normal blood Hemoglobin

- Informed consent

Exclusion Criteria:

- Liver disease

- Diabetic nephropathy

- Treatment with medications unpausable for 12 hours

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Other:
• GIP-infusion

• Sodium-chloride

• GLP-2 infusion

Locations
Country Name City State
Denmark University Hospital, Gentofte Hellerup Capital Region

Sponsors (2)
Lead Sponsor Collaborator
University Hospital, Gentofte, Copenhagen University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome
Type Measure Description Time frame Safety issue
Primary plasma-glucagon Area Under Curve at 0-90 min. and 90-180 min. No
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