Clinical Trials Logo
  1. Home
  2. Other
  3. NCT06377657

Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With T2DM

Diabetes Type 2 Clinical Trial

Official title:
METRNL Response, Plasma Oxidative and Antioxidant Indices to HIIT and Aloe Vera Supplementation in Patients With Diabetes Type 2

Clinical Trial Summary

Diabetes is a prevalent metabolic disease that leads to increased blood sugar levels due to insulin shortage or resistance. Type 2 diabetes is often linked to obesity, which can increase insulin resistance. Meteorin-like protein (METRNL) is a new secreted protein that affects insulin sensitivity and has been found to be negatively related to serum glucose levels in people with diabetes. Oxidative stress in diabetics can stimulate the production of inflammatory mediators, increasing the activity of the antioxidant system. Aloe vera, a widely used plant, has been used for treating diabetes, wound healing, tumors, and inflammatory bowel disease. It has anti-inflammatory, antioxidant, neuroprotective, antidepressant, and memory-enhancing effects. Exercise can improve diabetic patients' conditions by increasing the expression of GLUT4 protein and skeletal muscle. High-intensity interval training has been shown to increase the expression of the METORIN gene in human subjects and decrease MDA in type 2 diabetic patients. However, no studies have examined the simultaneous effect of exercise and Aloe vera on diabetes indicators. The present study aims to investigate the response of METRNL and some oxidative and antioxidant plasma indicators to high-intensity interval training and Aloe vera supplementation in type 2 diabetic men. The findings indicate that exercise and consumption of plants with anti-inflammatory and antioxidant properties can be effective in modulating the pathological effects of diabetes and increasing insulin sensitivity.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06377657
Study type Interventional
Source University of Nis
Contact
Status Completed
Phase N/A
Start date January 15, 2022
Completion date February 19, 2024
View Details
See also
  Status Clinical Trial Phase
Enrolling by invitation NCT05530356 - Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
Active, not recruiting NCT04954313 - Baseline Oral Health Study: UnCoVer the Connections to General Health Phase 4
Not yet recruiting NCT06437782 - Exploration of Health Literacy in Diabetes in Reunion Island and France
Completed NCT01354925 - Management of Type-2 Diabetic Patients Treated With Insulin During the Ramadan Phase 4
Completed NCT01206725 - Exercise Study on Cardiac Function in Patients With Diabetes Mellitus Type 2 and Diastolic Dysfunction N/A
Completed NCT00997282 - A Study of OPC-262 in Patients With Type 2 Diabetes Phase 2/Phase 3
Completed NCT00637546 - Gait and Balance of Diabetes Type 2 Patients Phase 2/Phase 3
Completed NCT00464880 - Effects of Aliskiren, Irbesartan, and the Combination in Hypertensive Patients With Type 2 Diabetes and Diabetic Nephropathy Phase 1/Phase 2
Withdrawn NCT02057497 - An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms N/A
Active, not recruiting NCT05014204 - Safety and Feasibility of Novel Therapy for Duodenal Mucosal Regeneration for Type II Diabetes N/A
Recruiting NCT03662217 - Personalized Nutrition for Diabetes Type 2 N/A
Completed NCT04276051 - Cryovagotomy Diabetes Trial N/A
Completed NCT02569684 - Effects of Prebiotics on GLP-1 in Type 2 Diabetes N/A
Active, not recruiting NCT01933529 - ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue) in Prediabetes and Type 2 Diabetes) Phase 2
Terminated NCT01722474 - Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness. N/A
Completed NCT00977262 - Postprandial Inflammation and Fatty Acids N/A
Completed NCT00518427 - Evaluate Quality of Life in Type 2 Diabetes, Before and After Change to Insuline Glargine Phase 4
Recruiting NCT05378620 - Project Dulce for Filipino-Americans With Type 2 Diabetes N/A
Recruiting NCT03834207 - A Study of the Usefulness & Usability of a Healthcare IT System for Managing Multi-morbidity and Poly-pharmacy N/A
Active, not recruiting NCT05228067 - Enhancing Brain Health by tDCS in Persons With Overweight and Obesity N/A