Diabetes Type 1 Clinical Trial
Official title:
Imaging of Islet Transplantation With PET and MRT
Islets of Langerhans intended for clinical transplantation are labelled with a radioactive tracer. The tracer is retained in viable cells of the transplant. At infusion (transplantation) of the islets into the portal vein the tracer can be followed for two hours with positron emission tomography (PET). Imaging and calculations can give estimates of the proportion of surveying islets and the rate of early destruction. Also the distribution of the islets into the liver can be viewed.
Background:
It is suspected that the current need for repeated islets transplantation to treat diabetes
type I is dependent on an early destruction of the islets when infused into the portal vein.
Aim:
To trace the fate of the islet at and after infusion into the portal vein.
Method:
Islets are labelled in vitro with a radioactive tracer that can be measured with positron
emission tomography. 10-20 percent of the graft is labelled. Just prior to start of infusion
labelled islets are mixed with unlabelled islets (80-90 percent of the graft). The tracer
used is FDG and stands for 2-[18F]-2-deoxy-D-glucose. At infusion the patient is placed in
the combined computer tomography and PET camera to follow the infusion. The imaging is
almost continuous for 2 h at and after infusion.
Expected results:
Calculations of proportion of surviving islets and rate of destruction. Localisation and
distribution of islets in the liver of the recipient.
;
Observational Model: Cohort, Time Perspective: Prospective
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