Diabetes Mellitus Clinical Trial
Official title:
Measurement of Retinal Venous Pressure and Endothelin-1 in Patients With Diabetes Mellitus
Measurement of the circulation in patients with diabetes mellitus and establish a link between retinal venous pressure (RVP) and endothelin (ET-1)levels.
Diabetic retinopathy and maculopathy are the main causes of visual loss. Hyperglycemia as
the main risk factor of diabetic retinopathy induced damage to retinal capillaries. These in
turn lead to hypoxia in the tissue and promote the release of VEGF (vascular endothelial
growth factor) , which in turn increases the vascular pathology. Simultaneously, there is an
increased expression of endothelin (ET-1). Endothelin increases vascular tone and regulates
the micro-and macro-vascular remodeling.
In ocular blood flow perfusion pressure plays an important role. While in healthy eyes a
spontaneous retinal venous pulsation is frequently observed, this is significantly less
frequent in diseased eyes. An increased venous pressure lowers the ocular perfusion
pressure, and increases the transmural pressure. A measurement of the retinal venous
pressure and the hormone ET-1 in the blood will give us a better knowledge of the
circulatory changes and their relationship to diabetes.
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