Diabetes Mellitus Clinical Trial
Official title:
Increased Calcaneal Spur Incidence in Patients With Obesity and Type 2 Diabetes Mellitus
Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to originate from chronic plantar fasciitis. Diabetes mellitus may contribute to the risk of CS by decreased ability of tissue repair and increased reactive ossification. Thus, the investigators aimed to determine CS incidence in asymptomatic obese subjects with and without type 2 diabetes mellitus (T2DM).
OBJECTIVE-Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to
originate from chronic plantar fasciitis. Diabetes mellitus may contribute to the risk of CS
by decreased ability of tissue repair and increased reactive ossification. Thus, the
investigators aimed to determine CS incidence in asymptomatic obese subjects with and
without type 2 diabetes mellitus (T2DM).
RESEARCH DESIGN AND METHODS—Ninety-three obese patients with T2DM and forty-two obese
subjects without any metabolic disturbances as control were evaluated with lateral calcaneal
x-ray in blinded fashion by a radiologist. All participants were informed and written
consents have been obtained. Control cases were subjected to 75g glucose challenge test and
glucose intolerant subjects were excluded.
RESULTS—T2DM and control groups were statistically similar in mean age (59±10.5 vs. 55±8
yrs, P=0.196, respectively) and mean body mass index (BMI)(35.1±4.3 vs. 33.1±3.3 kg/m2,
P=0.073, respectively). Existence of calcaneal spur was 72% in 93 patients (77%) in T2DM
group and 24 in 42 (57%) in control group. Groups were significantly different according to
existence of CS (P=0.023). Mean age and mean BMI were significantly higher in diabetic
patients with calcaneal spur than diabetic patients without calcaneal spur (p=0.001 and
p=0.015, respectively). There was positive correlation between existence of calcaneal spur
and peripheral neuropathy (p=0,043) in diabetics but no significant relation between
existence of CS and glycolysed hemoglobin levels or diabetes duration (all P>0.05).
CONCLUSIONS—Clinicians should pay attention the increased incidence of CS in patients with
T2DM to avoid foot complications.
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Observational Model: Case Control, Time Perspective: Prospective
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