Diabetes Mellitus Clinical Trial
Official title:
Multicenter Randomized Controlled Study of Rosuvastatin for Prevention of Contrast Induced Acute Kidney Injury in Patients With Diabetes and Slight to Moderate Renal Insufficient
The number of cardiac angiography and percutaneous coronary interventions (PCI) has
increased steadily in recent years. This has resulted in the increasing incidence of
contrast-induced acute kidney injury (CIAKI). Major risk factors for CIAKI include older
age, diabetes mellitus (DM), chronic kidney disease(CKD), the concurrent use of nephrotoxic
drugs, hemodynamic instability, etc. Importantly, DM appears to act as a risk multiplier,
meaning that in a patient with CKD it amplifies the risk of CIAKI.
The aim of this multicenter prospective, randomized, controlled study is to evaluate whether
statins treatment during the perioperative period would reduce the risk of CIAKI in a
high-risk population of patients with both type 2 diabetes mellitus (T2DM) and CKD
undergoing coronary angiography or noncoronary angiography, and evaluate the influence of
such potential benefit on short-term outcome.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
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