Diabetes Mellitus Clinical Trial
Official title:
Influence of Pioglitazone for Renal Transplant Function in Diabetics - a Double Blind Randomised Placebo Controlled Cross Over Study
The purpose of this study is to test whether pioglitazone is able to prevent the progression of diabetic nephropathy in kidney transplant recipients with diabetes mellitus.
About 30 % of kidney transplant recipients will develop diabetes mellitus. This condition is
a risk factor for graft dysfunction, graft loss and increased mortality of patients.
Inflammatory reactions within the graft and proteinuria are considered as pathogenetic
mechanisms.
Recent studies indicated that pioglitazone might have beneficial effects on the urinary
protein excretion of type 2 diabetic patients with diabetic nephropathy and was able to
reduce systemic inflammation.
This lead to the hypothesis that pioglitazone could improve proteinuria of kidney transplant
patients with diabetes.
Comparison: Effects of pioglitazone vs. placebo on proteinuria and renal function of kidney
transplant recipients in a cross over study.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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