Other Clinical Trial - Does Islet Transplantation Eliminate Hypoglycemia?

Status Not yet recruiting

Clinical Trial Summary

Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the pancreas of a person who did not have diabetes into a person with diabetes should eliminate high blood sugar levels. We wish to determine if it will also eliminate low blood sugar. To do so we will give insulin to lower the blood sugar, measure the levels of the hormones that normally raise blood sugar levels (e.g., glucagon and epinephrine) and then stop the insulin and see if blood sugar levels return to normal. Because we anticipate that the transplanted islets will produce insulin, but not glucagon, this study may also tell us if regulated insulin production alone can prevent hypoglycemia in humans.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Diabetes Mellitus

Clinical Trial Details

NCT number	NCT00006068
Study type	Interventional
Source	National Center for Research Resources (NCRR)
Contact	Philip E. Cryer, M.D.
Phone	1-314-362-7635
Email	pcryer@imgate.wustl.edu
Status	Not yet recruiting
Phase	N/A

View Details

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