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Effects of Adding Triamcinolone Acetonide to Conbercept Treatment for Refractory Diabetic Macular Edema (CONTE) — CONTE  

Diabetes Mellitus, Type 2 Clinical Trial

Official title:
Effects of Adding Triamcinolone Acetonide to Conbercept in Diabetic Macular Edema With Limited Response to Anti-VEGF Treatment After One Injection

Clinical Trial Summary

This study aimed to compare intravitreous conbercept alone with conbercept plus intravitreous triamcinolone acetonide in DME eyes which showed limited response to anti-VEGF treatment after one injection.

Clinical Trial Description

Some eyes with diabetic macular edema (DME) were not sensitive to anti-vascular endothelial growth factor (anti-VEGF) therapy and required continuous injections. Delayed control of macular edema might cause irreversible function loss. To predict the response to anti-VEGF treatment according to the CST change after one injection was proved reasonable recently. Adding intravitreous corticosteroids to the treatment regimen at early time might result in better outcomes than anti-VEGF therapy alone. Patients with diagnosis of refractory diabetic macular edema, confirmed by fluorangiography and optical coherence tomography (OCT), with limited response to one intravitreal anti-VEGF injection will be enrolled in the study. The enrolled patients will be randomized for the addition or not of the triamcinolone to intravitreal therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04627402
Study type Interventional
Source Zhongshan Ophthalmic Center, Sun Yat-sen University
Contact Qiuyi Liang, BS
Phone +86 20 66683995
Email liubq6@mail.sysu.edu.cn
Status Recruiting
Phase N/A
Start date November 12, 2020
Completion date December 31, 2021
View Details
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