Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Cynara Scolymus Extract for Treatment of Diabetes Mellitus Type 2, a Pilot Clinical Trial Clinical Study Protocol
Edible parts of the artichoke plant (Cynara cardunculus, Cynara scolymus) are traditionally
known in folk-medicine for lipid lowering and choleretic effects. Furthermore, antidiabetic
effects are described. In the past year's research attributed health promoting effects to the
main active compounds chlorogenic acid, luteolin and apigenin. Present literature indicates
potential antidiabetic effects by different mechanisms like downregulation of
gluconeogenesis, increased GLP-1 secretion and modification of insulin signalling. Up to now
only few human clinical trials provide insufficient data to conclude the therapeutic
potential of cynara scolymus extract in the treatment of type 2 diabetes.
The primary objective is to evaluate the antidiabetic effect and the mechanisms of glucose
lowering by a 12-week treatment with a highly-standardized extract of cynara scolymus in
subjects with diabetes mellitus type 2 compared to placebo.
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