Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Effect of Extracorporeal Shock Wave Therapy (ESWT) on Erectile Dysfunction in Type 2 Diabetes Mellitus Patients
Diabetes mellitus (DM) is known not only for its widespread prevalence, but also for its significant complications including cerebrovascular disease, coronary artery disease, renal failure, vision loss, and neuropathy. Of particular importance to sexual medicine, diabetes has also been strongly associated with erectile dysfunction (ED).ED is defined as the inability to obtain and/or maintain the erection firm enough to achieve a successful sexual intercourse on a regular basis. It is a more common condition in males with type 2 DM. In the field of sexual medicine numerous studies have shown that extracorporal shock wave therapy (ESWT) is safe, noninvasive, and, most importantly, an effective method for treating vascular ED
ED in DM is often complex and caused by several mechanisms including vascular disease,
autonomic neuropathy, hormonal imbalance, and psychogenic factors. However, as the
endothelial dysfunction is an important factor contributing to the development of ED in
diabetic patients, such patients can be resistant to phosphodiesterase 5 inhibitors (PDE5I)
like sildenafil therapy. There are reports of lower efficacy of sildenafil in DM patients
compared to general population.In the field of sexual medicine numerous studies have shown
that ESWT is safe, noninvasive, and, most importantly, an effective method for treating
vascular ED
Before starting the study, clearance will be obtained from the institutional ethical
committee and prior informed consent of all the participants will be obtained before
conducting the study. Patients will be recruited from outpatient clinic of andrology (Cairo
University Hospitals). The patients were randomly divided into two equal groups:
Group (1): (Study group): Men in this group (n= 20) men receive extracorporeal shock wave
(ESWT) twice weekly for 3 consecutive weeks and repeated after a 3-week rest period, for a
total of 12 treatment sessions+sildenafil 5mg) Group (2): (Control group):) will receive sham
treatment underwent identical therapy with ESWT application with a similar appearance and
sound as the active low intensity ESWT+sildenafil 5mg
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