Diabetes Mellitus, Type 2 Clinical Trial
Official title:
24-hour Blood Pressure Dynamics and Autonomic Adrenergic Regulation in Type 2 Diabetics
Autonomic neuropathy is a common complication of type 2 diabetes mellitus. Symptoms from
cardiovascular autonomic neuropathy include, dizziness, orthostatic hypotension and
insufficient heart rate and blood pressure (BP) regulation during physical exertion. The
degree of cardiovascular autonomic neuropathy is most commonly measured as cardiac autonomic
neuropathy based on at least two abnormal cardiac reflex tests, which primarily measures
parasympathetic indices of the autonomic nervous system (ANS).
Few measures are available for quantifying the sympathetic/adrenergic branch of the ANS.
Circadian changes in BP is a documented measure of BP variability, regulated centrally by a
multitude of centers. A growing number of studies indicate that a diminished BP variability
is associated with increased cardiovascular risk and injury. The ANS plays a pivotal role in
the execution of these circadian BP changes, mainly through sympathetic adrenergic nerve
fibers
Few studies have investigated the applicability of 24-hour indices as predictor for autonomic
adrenergic dysfunction. No previous studies have investigated the association between
clinical markers of adrenergic function, and 24-hour blood pressure indices in type 2
diabetes.
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