Diabetes Mellitus, Type 2 Clinical Trial
Official title:
Effects of Dietary Fiber on Glucose Control in Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to determine the effect of a commercial dietary fiber supplement on patients with type 2 diabetes mellitus, in the way of glucose control, insulin action in the body, and the gut microbiota (bacteria) abundance.
Fiber supplements such as psyllium are known to be beneficial to glycemic control in patients
with type 2 diabetes mellitus (T2DM). Gut microbiota has a role in regulating host energy
metabolism and systemic inflammation by several pathways such as short-chain fatty acid
production, fasting-induced adipose factor expression, endocannabinoid system, and gut
epithelial permeability. As dietary components can influence the composition of the
microbiota, we hypothesized that fiber supplements could modify gut microbiota and
consequently affect glycemic control and inflammatory condition in patients with T2DM.
The primary outcome was to assess the effect of fiber on glucose control (by comparing
fasting glucose and glycoalbumin), insulin secretion and sensitivity. Secondary outcomes were
the changes abundance of microbiota, incretins, and lipopolysaccharide (LPS).
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